1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)
1_MSLLN 6_ PVLLP 11_ PKVKA 16_ YLSQG 21_ ERFIK 26_ WDDET 31_ TVASP 36_ VILRV 41_ DPKGY 46_ YLYWT 51_ YQSKE 56_ MEFLD 61_ ITSIR 66_ DTRFG 71_ KFAKM 76_ PKSQK 81_ LRDVF 86_ NMDFP 91_ DNSFL 96_ LKTLT 101_ VVSGP 106_ DMVDL 111_ TFHNF 116_ VSYKE 121_ NVGKA 126_ WAEDV 131_ LALVK 136_ HPLTA 141_ NASRS 146_ TFLDK 151_ ILVKL 156_ KMQLN 161_ SEGKI 166_ PVKNF 171_ FQMFP 176_ ADRKR 181_ VEAAL 186_ SACHL 191_ PKGKN 196_ DAINP 201_ EDFPE 206_ PVYKS 211_ FLMSL 216_ CPRPE 221_ IDEIF 226_ TSYHA 231_ KAKPY 236_ MTKEH 241_ LTKFI 246_ NQKQR 251_ DSRLN 256_ SLLFP 261_ PARPD 266_ QVQGL 271_ IDKYE 276_ PSGIN 281_ AQRGQ 286_ LSPEG 291_ MVWFL 296_ CGPEN 301_ SVLAQ 306_ DKLLL 311_ HHDMT 316_ QPLNH 321_ YFINS 326_ SHNTY 331_ LTAGQ 336_ FSGLS 341_ SAEMY 346_ RQVLL 351_ SGCRC 356_ VELDC 361_ WKGKP 366_ PDEEP 371_ IITHG 376_ FTMTT 381_ DIFFK 386_ EAIEA 391_ IAESA 396_ FKTSP 401_ YPIIL 406_ SFENH 411_ VDSPR 416_ QQAKM 421_ AEYCR 426_ TIFGD 431_ MLLTE 436_ PLEKF 441_ PLKPG 446_ VPLPS 451_ PEDLR 456_ GKILI 461_ KNKKN 466_ QFSGP 471_ TSSSK 476_ DTGGE 481_ AEGSS 486_ PPSAP 491_ AGEGT 496_ VWAGE 501_ EGTEL 506_ EEEEV 511_ EEEEE 516_ EESGN 521_ LDEEE 526_ IKKMQ 531_ SDEGT 536_ AGLEV 541_ TAYEE 546_ MSSLV 551_ NYIQP 556_ TKFVS 561_ FEFSA 566_ QKNRS 571_ YVISS 576_ FTELK 581_ AYDLL 586_ SKASV 591_ QFVDY 596_ NKRQM 601_ SRIYP 606_ KGTRM 611_ DSSNY 616_ MPQMF 621_ WNAGC 626_ QMVAL 631_ NFQTM 636_ DLPMQ 641_ QNMAV 646_ FEFNG 651_ QSGYL 656_ LKHEF 661_ MRRPD 666_ KQFNP 671_ FSVDR 676_ IDVVV 681_ ATTLS 686_ ITVIS 691_ GQFLS 696_ ERSVR 701_ TYVEV 706_ ELFGL 711_ PGDPK 716_ RRYRT 721_ KLSPS 726_ TNSIN 731_ PVWKE 736_ EPFVF 741_ EKILM 746_ PELAS 751_ LRVAV 756_ MEEGN 761_ KFLGH 766_ RIIPI 771_ NALNS 776_ GYHHL 781_ CLHSE 786_ SNMPL 791_ TMPAL 796_ FIFLE 801_ MKDYI 806_ PGAWA 811_ DLTVA 816_ LANPI 821_ KFFSA 826_ HDTKS 831_ VKLKE 836_ AMGGL 841_ PEKPF 846_ PLASP 851_ VASQV 856_ NGALA 861_ PTSNG 866_ SPAAR 871_ AGARE 876_ EAMKE 881_ AAEPR 886_ TASLE 891_ ELREL 896_ KGVVK 901_ LQRRH 906_ EKELR 911_ ELERR 916_ GARRW 921_ EELLQ 926_ RGAAQ 931_ LAELG 936_ PPGVG 941_ GVGAC 946_ KLGPG 951_ KGSRK 956_ KRSLP 961_ REESA 966_ GAAPG 971_ EGPEG 976_ VDGRV 981_ RELKD 986_ RLELE 991_ LLRQG 996_ EEQYE 1001_ CVLKR 1006_ KEQHV 1011_ AEQIS 1016_ KMMEL 1021_ AREKQ 1026_ AAELK 1031_ ALKET 1036_ SENDT 1041_ KEMKK 1046_ KLETK 1051_ RLERI 1056_ QGMTK 1061_ VTTDK 1066_ MAQER 1071_ LKREI 1076_ NNSHI 1081_ QEVVQ 1086_ VIKQM 1091_ TENLE 1096_ RHQEK 1101_ LEEKQ 1106_ AACLE 1111_ QIREM 1116_ EKQFQ 1121_ KEALA 1126_ EYEAR 1131_ MKGLE 1136_ AEVKE 1141_ SVRAC 1146_ LRTCF 1151_ PSEAK 1156_ DKPER 1161_ ACECP 1166_ PELCE 1171_ QDPLI 1176_AKADA
1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity)