Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)
1_MAAAA 6_ KPNNL 11_ SLVVH 16_ GPGDL 21_ RLENY 26_ PIPEP 31_ GPNEV 36_ LLRMH 41_ SVGIC 46_ GSDVH 51_ YWEYG 56_ RIGNF 61_ IVKKP 66_ MVLGH 71_ EASGT 76_ VEKVG 81_ SSVKH 86_ LKPGD 91_ RVAIE 96_ PGAPR 101_ ENDEF 106_ CKMGR 111_ YNLSP 116_ SIFFC 121_ ATPPD 126_ DGNLC 131_ RFYKH 136_ NAAFC 141_ YKLPD 146_ NVTFE 151_ EGALI 156_ EPLSV 161_ GIHAC 166_ RRGGV 171_ TLGHK 176_ VLVCG 181_ AGPIG 186_ MVTLL 191_ VAKAM 196_ GAAQV 201_ VVTDL 206_ SATRL 211_ SKAKE 216_ IGADL 221_ VLQIS 226_ KESPQ 231_ EIARK 236_ VEGQL 241_ GCKPE 246_ VTIEC 251_ TGAEA 256_ SIQAG 261_ IYATR 266_ SGGNL 271_ VLVGL 276_ GSEMT 281_ TVPLL 286_ HAAIR 291_ EVDIK 296_ GVFRY 301_ CNTWP 306_ VAISM 311_ LASKS 316_ VNVKP 321_ LVTHR 326_ FPLEK 331_ ALEAF 336_ ETFKK 341_ GLGLK 346_ IMLKC 351_DPSDQ
1: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:25105142, PubMed:29966615). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415)