Gene name: PSG9

Uniprot entry:

Q00887

Protein names:

Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7)

Protein sequence:

1_MGPLP 6_ APSCT 11_ QRITW 16_ KGLLL 21_ TASLL 26_ NFWNP 31_ PTTAE 36_ VTIEA 41_ QPPKV 46_ SEGKD 51_ VLLLV 56_ HNLPQ 61_ NLPGY 66_ FWYKG 71_ EMTDL 76_ YHYII 81_ SYIVD 86_ GKIII 91_ YGPAY 96_ SGRET 101_ VYSNA 106_ SLLIQ 111_ NVTRK 116_ DAGTY 121_ TLHII 126_ KRGDE 131_ TREEI 136_ RHFTF 141_ TLYLE 146_ TPKPY 151_ ISSSN 156_ LNPRE 161_ AMEAV 166_ RLICD 171_ PETLD 176_ ASYLW 181_ WMNGQ 186_ SLPVT 191_ HRLQL 196_ SKTNR 201_ TLYLF 206_ GVTKY 211_ IAGPY 216_ ECEIR 221_ NPVSA 226_ SRSDP 231_ VTLNL 236_ LPKLP 241_ IPYIT 246_ INNLN 251_ PRENK 256_ DVLAF 261_ TCEPK 266_ SENYT 271_ YIWWL 276_ NGQSL 281_ PVSPG 286_ VKRPI 291_ ENRIL 296_ ILPSV 301_ TRNET 306_ GPYQC 311_ EIRDR 316_ YGGLR 321_ SNPVI 326_ LNVLY 331_ GPDLP 336_ RIYPS 341_ FTYYR 346_ SGENL 351_ DLSCF 356_ TESNP 361_ PAEYF 366_ WTING 371_ KFQQS 376_ GQKLF 381_ IPQIT 386_ RNHSG 391_ LYACS 396_ VHNSA 401_ TGKEI 406_ SKSMT 411_ VKVSG 416_ PCHGD 421_LTESQ

Protein annotations

Protein functions:

1: Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 (PubMed:27389696). The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells (PubMed:27389696). Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696). Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells (PubMed:27389696). May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 (PubMed:27389696)