Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
1_MASGR 6_ ARCTR 11_ KLRNW 16_ VVEQV 21_ ESGQF 26_ PGVCW 31_ DDTAK 36_ TMFRI 41_ PWKHA 46_ GKQDF 51_ REDQD 56_ AAFFK 61_ AWAIF 66_ KGKYK 71_ EGDTG 76_ GPAVW 81_ KTRLR 86_ CALNK 91_ SSEFK 96_ EVPER 101_ GRMDV 106_ AEPYK 111_ VYQLL 116_ PPGIV 121_ SGQPG 126_ TQKVP 131_ SKRQH 136_ SSVSS 141_ ERKEE 146_ EDAMQ 151_ NCTLS 156_ PSVLQ 161_ DSLNN 166_ EEEGA 171_ SGGAV 176_ HSDIG 181_ SSSSS 186_ SSPEP 191_ QEVTD 196_ TTEAP 201_ FQGDQ 206_ RSLEF 211_ LLPPE 216_ PDYSL 221_ LLTFI 226_ YNGRV 231_ VGEAQ 236_ VQSLD 241_ CRLVA 246_ EPSGS 251_ ESSME 256_ QVLFP 261_ KPGPL 266_ EPTQR 271_ LLSQL 276_ ERGIL 281_ VASNP 286_ RGLFV 291_ QRLCP 296_ IPISW 301_ NAPQA 306_ PPGPG 311_ PHLLP 316_ SNECV 321_ ELFRT 326_ AYFCR 331_ DLVRY 336_ FQGLG 341_ PPPKF 346_ QVTLN 351_ FWEES 356_ HGSSH 361_ TPQNL 366_ ITVKM 371_ EQAFA 376_ RYLLE 381_ QTPEQ 386_QAAIL
1: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state