E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
1_MCNTN 6_ MSVPT 11_ DGAVT 16_ TSQIP 21_ ASEQE 26_ TLVRP 31_ KPLLL 36_ KLLKS 41_ VGAQK 46_ DTYTM 51_ KEVLF 56_ YLGQY 61_ IMTKR 66_ LYDEK 71_ QQHIV 76_ YCSND 81_ LLGDL 86_ FGVPS 91_ FSVKE 96_ HRKIY 101_ TMIYR 106_ NLVVV 111_ NQQES 116_ SDSGT 121_ SVSEN 126_ RCHLE 131_ GGSDQ 136_ KDLVQ 141_ ELQEE 146_ KPSSS 151_ HLVSR 156_ PSTSS 161_ RRRAI 166_ SETEE 171_ NSDEL 176_ SGERQ 181_ RKRHK 186_ SDSIS 191_ LSFDE 196_ SLALC 201_ VIREI 206_ CCERS 211_ SSSES 216_ TGTPS 221_ NPDLD 226_ AGVSE 231_ HSGDW 236_ LDQDS 241_ VSDQF 246_ SVEFE 251_ VESLD 256_ SEDYS 261_ LSEEG 266_ QELSD 271_ EDDEV 276_ YQVTV 281_ YQAGE 286_ SDTDS 291_ FEEDP 296_ EISLA 301_ DYWKC 306_ TSCNE 311_ MNPPL 316_ PSHCN 321_ RCWAL 326_ RENWL 331_ PEDKG 336_ KDKGE 341_ ISEKA 346_ KLENS 351_ TQAEE 356_ GFDVP 361_ DCKKT 366_ IVNDS 371_ RESCV 376_ EENDD 381_ KITQA 386_ SQSQE 391_ SEDYS 396_ QPSTS 401_ SSIIY 406_ SSQED 411_ VKEFE 416_ REETQ 421_ DKEES 426_ VESSL 431_ PLNAI 436_ EPCVI 441_ CQGRP 446_ KNGCI 451_ VHGKT 456_ GHLMA 461_ CFTCA 466_ KKLKK 471_ RNKPC 476_ PVCRQ 481_ PIQMI 486_VLTYF
1: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903)