Perilipin-5 (Lipid storage droplet protein 5)
1_MSEEE 6_ AAQIP 11_ RSSVW 16_ EQDQQ 21_ NVVQR 26_ VVALP 31_ LVRAT 36_ CTAVC 41_ DVYSA 46_ AKDRH 51_ PLLGS 56_ ACRLA 61_ ENCVC 66_ GLTTR 71_ ALDHA 76_ QPLLE 81_ HLQPQ 86_ LATMN 91_ SLACR 96_ GLDKL 101_ EEKLP 106_ FLQQP 111_ SETVV 116_ TSAKD 121_ VVASS 126_ VTGVV 131_ DLARR 136_ GRRWS 141_ VELKR 146_ SVSHA 151_ VDVVL 156_ EKSEE 161_ LVDHF 166_ LPMTE 171_ EELAA 176_ LAAEA 181_ EGPEV 186_ GSVED 191_ QRRQQ 196_ GYFVR 201_ LGSLS 206_ ARIRH 211_ LAYEH 216_ SVGKL 221_ RQSKH 226_ RAQDT 231_ LAQLQ 236_ ETLEL 241_ IDHMQ 246_ CGVTP 251_ TAPAC 256_ PGKVH 261_ ELWGE 266_ WGQRP 271_ PESRR 276_ RSQAE 281_ LETLV 286_ LSRSL 291_ TQELQ 296_ GTVEA 301_ LESSV 306_ RGLPA 311_ GAQEK 316_ VAEVR 321_ RSVDA 326_ LQTAF 331_ ADARC 336_ FRDVP 341_ AAALA 346_ EGRGR 351_ VAHAH 356_ ACVDE 361_ LLELV 366_ VQAVP 371_ LPWLV 376_ GPFAP 381_ ILVER 386_ PEPLP 391_ DLADL 396_ VDEVI 401_ GGPDP 406_ RWAHL 411_ DWPAQ 416_ QRAWE 421_ AEHRD 426_ GSGNG 431_ DGDRM 436_ GVAGD 441_ ICEQE 446_ PETPS 451_ CPVKH 456_TLMPE
1: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity)