Nucleolysin TIAR (TIA-1-related protein)
1_MMEDD 6_ GQPRT 11_ LYVGN 16_ LSRDV 21_ TEVLI 26_ LQLFS 31_ QIGPC 36_ KSCKM 41_ ITEHT 46_ SNDPY 51_ CFVEF 56_ YEHRD 61_ AAAAL 66_ AAMNG 71_ RKILG 76_ KEVKV 81_ NWATT 86_ PSSQK 91_ KDTSN 96_ HFHVF 101_ VGDLS 106_ PEITT 111_ EDIKS 116_ AFAPF 121_ GKISD 126_ ARVVK 131_ DMATG 136_ KSKGY 141_ GFVSF 146_ YNKLD 151_ AENAI 156_ VHMGG 161_ QWLGG 166_ RQIRT 171_ NWATR 176_ KPPAP 181_ KSTQE 186_ NNTKQ 191_ LRFED 196_ VVNQS 201_ SPKNC 206_ TVYCG 211_ GIASG 216_ LTDQL 221_ MRQTF 226_ SPFGQ 231_ IMEIR 236_ VFPEK 241_ GYSFV 246_ RFSTH 251_ ESAAH 256_ AIVSV 261_ NGTTI 266_ EGHVV 271_ KCYWG 276_ KESPD 281_ MTKNF 286_ QQVDY 291_ SQWGQ 296_ WSQVY 301_ GNPQQ 306_ YGQYM 311_ ANGWQ 316_ VPPYG 321_ VYGQP 326_ WNQQG 331_ FGVDQ 336_ SPSAA 341_ WMGGF 346_ GAQPP 351_ QGQAP 356_ PPVIP 361_ PPNQA 366_GYGMA
1: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:10613902, PubMed:1326761, PubMed:17488725, PubMed:8576255). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761)