Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
1_MALAG 6_ APAGG 11_ PCAPA 16_ LEALL 21_ GAGAL 26_ RLLDS 31_ SQIVI 36_ ISAAQ 41_ DASAP 46_ PAPTG 51_ PAAPA 56_ AGPCD 61_ PDLLL 66_ FATPQ 71_ APRPT 76_ PSAPR 81_ PALGR 86_ PPVKR 91_ RLDLE 96_ TDHQY 101_ LAESS 106_ GPARG 111_ RGRHP 116_ GKGVK 121_ SPGEK 126_ SRYET 131_ SLNLT 136_ TKRFL 141_ ELLSH 146_ SADGV 151_ VDLNW 156_ AAEVL 161_ KVQKR 166_ RIYDI 171_ TNVLE 176_ GIQLI 181_ AKKSK 186_ NHIQW 191_ LGSHT 196_ TVGVG 201_ GRLEG 206_ LTQDL 211_ RQLQE 216_ SEQQL 221_ DHLMN 226_ ICTTQ 231_ LRLLS 236_ EDTDS 241_ QRLAY 246_ VTCQD 251_ LRSIA 256_ DPAEQ 261_ MVMVI 266_ KAPPE 271_ TQLQA 276_ VDSSE 281_ NFQIS 286_ LKSKQ 291_ GPIDV 296_ FLCPE 301_ ETVGG 306_ ISPGK 311_ TPSQE 316_ VTSEE 321_ ENRAT 326_ DSATI 331_ VSPPP 336_ SSPPS 341_ SLTTD 346_ PSQSL 351_ LSLEQ 356_ EPLLS 361_ RMGSL 366_ RAPVD 371_ EDRLS 376_ PLVAA 381_ DSLLE 386_ HVRED 391_ FSGLL 396_ PEEFI 401_ SLSPP 406_ HEALD 411_ YHFGL 416_ EEGEG 421_ IRDLF 426_ DCDFG 431_DLTPL
1: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599)