Insulinoma-associated protein 1 (Zinc finger protein IA-1)
1_MPRGF 6_ LVKRS 11_ KKSTP 16_ VSYRV 21_ RGGED 26_ GDRAL 31_ LLSPS 36_ CGGAR 41_ AEPPA 46_ PSPVP 51_ GPLPP 56_ PPPAE 61_ RAHAA 66_ LAAAL 71_ ACAPG 76_ PQPPP 81_ QGPRA 86_ AHFGN 91_ PEAAH 96_ PAPLY 101_ SPTRP 106_ VSREH 111_ EKHKY 116_ FERSF 121_ NLGSP 126_ VSAES 131_ FPTPA 136_ ALLGG 141_ GGGGG 146_ ASGAG 151_ GGGTC 156_ GGDPL 161_ LFAPA 166_ ELKMG 171_ TAFSA 176_ GAEAA 181_ RGPGP 186_ GPPLP 191_ PAAAL 196_ RPPGK 201_ RPPPP 206_ TAAEP 211_ PAKAV 216_ KAPGA 221_ KKPKA 226_ IRKLH 231_ FEDEV 236_ TTSPV 241_ LGLKI 246_ KEGPV 251_ EAPRG 256_ RAGGA 261_ ARPLG 266_ EFICQ 271_ LCKEE 276_ YADPF 281_ ALAQH 286_ KCSRI 291_ VRVEY 296_ RCPEC 301_ AKVFS 306_ CPANL 311_ ASHRR 316_ WHKPR 321_ PAPAA 326_ ARAPE 331_ PEAAA 336_ RAEAR 341_ EAPGG 346_ GSDRD 351_ TPSPG 356_ GVSES 361_ GSEDG 366_ LYECH 371_ HCAKK 376_ FRRQA 381_ YLRKH 386_ LLAHH 391_ QALQA 396_ KGAPL 401_ APPAE 406_ DLLAL 411_ YPGPD 416_ EKAPQ 421_ EAAGD 426_ GEGAG 431_ VLGLS 436_ ASAEC 441_ HLCPV 446_ CGESF 451_ ASKGA 456_ QERHL 461_ RLLHA 466_ AQVFP 471_ CKYCP 476_ ATFYS 481_ SPGLT 486_ RHINK 491_ CHPSE 496_ NRQVI 501_LLQVP
1: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation