Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)
1_MAPKR 6_ QSPLP 11_ PQKKK 16_ PRPPP 21_ ALGPE 26_ ETSAS 31_ AGLPK 36_ KGEKE 41_ QQEAI 46_ EHIDE 51_ VQNEI 56_ DRLNE 61_ QASEE 66_ ILKVE 71_ QKYNK 76_ LRQPF 81_ FQKRS 86_ ELIAK 91_ IPNFW 96_ VTTFV 101_ NHPQV 106_ SALLG 111_ EEDEE 116_ ALHYL 121_ TRVEV 126_ TEFED 131_ IKSGY 136_ RIDFY 141_ FDENP 146_ YFENK 151_ VLSKE 156_ FHLNE 161_ SGDPS 166_ SKSTE 171_ IKWKS 176_ GKDLT 181_ KRSSQ 186_ TQNKA 191_ SRKRQ 196_ HEEPE 201_ SFFTW 206_ FTDHS 211_ DAGAD 216_ ELGEV 221_ IKDDI 226_ WPNPL 231_ QYYLV 236_ PDMDD 241_ EEGEG 246_ EEDDD 251_ DDEEE 256_ EGLED 261_ IDEEG 266_ DEDEG 271_ EEDED 276_ DDEGE 281_EGEED
1: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher