Sodium channel protein type 7 subunit alpha (Putative voltage-gated sodium channel subunit alpha Nax) (Sodium channel protein cardiac and skeletal muscle subunit alpha) (Sodium channel protein type VII subunit alpha)
1_MLASP 6_ EPKGL 11_ VPFTK 16_ ESFEL 21_ IKQHI 26_ AKTHN 31_ EDHEE 36_ EDLKP 41_ TPDLE 46_ VGKKL 51_ PFIYG 56_ NLSQG 61_ MVSEP 66_ LEDVD 71_ PYYYK 76_ KKNTF 81_ IVLNK 86_ NRTIF 91_ RFNAA 96_ SILCT 101_ LSPFN 106_ CIRRT 111_ TIKVL 116_ VHPFF 121_ QLFIL 126_ ISVLI 131_ DCVFM 136_ SLTNL 141_ PKWRP 146_ VLENT 151_ LLGIY 156_ TFEIL 161_ VKLFA 166_ RGVWA 171_ GSFSF 176_ LGDPW 181_ NWLDF 186_ SVTVF 191_ EVIIR 196_ YSPLD 201_ FIPTL 206_ QTART 211_ LRILK 216_ IIPLN 221_ QGLKS 226_ LVGVL 231_ IHCLK 236_ QLIGV 241_ IILTL 246_ FFLSI 251_ FSLIG 256_ MGLFM 261_ GNLKH 266_ KCFRW 271_ PQENE 276_ NETLH 281_ NRTGN 286_ PYYIR 291_ ETENF 296_ YYLEG 301_ ERYAL 306_ LCGNR 311_ TDAGQ 316_ CPEGY 321_ VCVKA 326_ GINPD 331_ QGFTN 336_ FDSFG 341_ WALFA 346_ LFRLM 351_ AQDYP 356_ EVLYH 361_ QILYA 366_ SGKVY 371_ MIFFV 376_ VVSFL 381_ FSFYM 386_ ASLFL 391_ GILAM 396_ AYEEE 401_ KQRVG 406_ EISKK 411_ IEPKF 416_ QQTGK 421_ ELQEG 426_ NETDE 431_ AKTIQ 436_ IEMKK 441_ RSPIS 446_ TDTSL 451_ DVLED 456_ ATLRH 461_ KEELE 466_ KSKKI 471_ CPLYW 476_ YKFAK 481_ TFLIW 486_ NCSPC 491_ WLKLK 496_ EFVHR 501_ IIMAP 506_ FTDLF 511_ LIICI 516_ ILNVC 521_ FLTLE 526_ HYPMS 531_ KQTNT 536_ LLNIG 541_ NLVFI 546_ GIFTA 551_ EMIFK 556_ IIAMH 561_ PYGYF 566_ QVGWN 571_ IFDSM 576_ IVFHG 581_ LIELC 586_ LANVA 591_ GMALL 596_ RLFRM 601_ LRIFK 606_ LGKYW 611_ PTFQI 616_ LMWSL 621_ SNSWV 626_ ALKDL 631_ VLLLF 636_ TFIFF 641_ SAAFG 646_ MKLFG 651_ KNYEE 656_ FVCHI 661_ DKDCQ 666_ LPRWH 671_ MHDFF 676_ HSFLN 681_ VFRIL 686_ CGEWV 691_ ETLWD 696_ CMEVA 701_ GQSWC 706_ IPFYL 711_ MVILI 716_ GNLLV 721_ LYLFL 726_ ALVSS 731_ FSSCK 736_ DVTAE 741_ ENNEA 746_ KNLQL 751_ AVARI 756_ KKGIN 761_ YVLLK 766_ ILCKT 771_ QNVPK 776_ DTMDH 781_ VNEVY 786_ VKEDI 791_ SDHTL 796_ SELSN 801_ TQDFL 806_ KDKEK 811_ SSGTE 816_ KNATE 821_ NESQS 826_ LIPSP 831_ SVSET 836_ VPIAS 841_ GESDI 846_ ENLDN 851_ KEIQS 856_ KSGDG 861_ GSKEK 866_ IKQSS 871_ SSECS 876_ TVDIA 881_ ISEEE 886_ EMFYG 891_ GERSK 896_ HLKNG 901_ CRRGS 906_ SLGQI 911_ SGASK 916_ KGKIW 921_ QNIRK 926_ TCCKI 931_ VENNW 936_ FKCFI 941_ GLVTL 946_ LSTGT 951_ LAFED 956_ IYMDQ 961_ RKTIK 966_ ILLEY 971_ ADMIF 976_ TYIFI 981_ LEMLL 986_ KWMAY 991_ GFKAY 996_ FSNGW 1001_ YRLDF 1006_ VVVIV 1011_ FCLSL 1016_ IGKTR 1021_ EELKP 1026_ LISMK 1031_ FLRPL 1036_ RVLSQ 1041_ FERMK 1046_ VVVRA 1051_ LIKTT 1056_ LPTLN 1061_ VFLVC 1066_ LMIWL 1071_ IFSIM 1076_ GVDLF 1081_ AGRFY 1086_ ECIDP 1091_ TSGER 1096_ FPSSE 1101_ VMNKS 1106_ RCESL 1111_ LFNES 1116_ MLWEN 1121_ AKMNF 1126_ DNVGN 1131_ GFLSL 1136_ LQVAT 1141_ FNGWI 1146_ TIMNS 1151_ AIDSV 1156_ AVNIQ 1161_ PHFEV 1166_ NIYMY 1171_ CYFIN 1176_ FIIFG 1181_ VFLPL 1186_ SMLIT 1191_ VIIDN 1196_ FNKHK 1201_ IKLGG 1206_ SNIFI 1211_ TVKQR 1216_ KQYRR 1221_ LKKLM 1226_ YEDSQ 1231_ RPVPR 1236_ PLNKL 1241_ QGFIF 1246_ DVVTS 1251_ QAFNV 1256_ IVMVL 1261_ ICFQA 1266_ IAMMI 1271_ DTDVQ 1276_ SLQMS 1281_ IALYW 1286_ INSIF 1291_ VMLYT 1296_ MECIL 1301_ KLIAF 1306_ RCFYF 1311_ TIAWN 1316_ IFDFM 1321_ VVIFS 1326_ ITGLC 1331_ LPMTV 1336_ GSYLV 1341_ PPSLV 1346_ QLILL 1351_ SRIIH 1356_ MLRLG 1361_ KGPKV 1366_ FHNLM 1371_ LPLML 1376_ SLPAL 1381_ LNIIL 1386_ LIFLV 1391_ MFIYA 1396_ VFGMY 1401_ NFAYV 1406_ KKEAG 1411_ INDVS 1416_ NFETF 1421_ GNSML 1426_ CLFQV 1431_ AIFAG 1436_ WDGML 1441_ DAIFN 1446_ SKWSD 1451_ CDPDK 1456_ INPGT 1461_ QVRGD 1466_ CGNPS 1471_ VGIFY 1476_ FVSYI 1481_ LISWL 1486_ IIVNM 1491_ YIVVV 1496_ MEFLN 1501_ IASKK 1506_ KNKTL 1511_ SEDDF 1516_ RKFFQ 1521_ VWKRF 1526_ DPDRT 1531_ QYIDS 1536_ SKLSD 1541_ FAAAL 1546_ DPPLF 1551_ MAKPN 1556_ KGQLI 1561_ ALDLP 1566_ MAVGD 1571_ RIHCL 1576_ DILLA 1581_ FTKRV 1586_ MGQDV 1591_ RMEKV 1596_ VSEIE 1601_ SGFLL 1606_ ANPFK 1611_ ITCEP 1616_ ITTTL 1621_ KRKQE 1626_ AVSAT 1631_ IIQRA 1636_ YKNYR 1641_ LRRND 1646_ KNTSD 1651_ IHMID 1656_ GDRDV 1661_ HATKE 1666_ GAYFD 1671_ KAKEK 1676_SPIQS
1: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (PubMed:26537257)