CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
1_MSRGL 6_ QLLLL 11_ SCAYS 16_ LAPAT 21_ PEVKV 26_ ACSED 31_ VDLPC 36_ TAPWD 41_ PQVPY 46_ TVSWV 51_ KLLEG 56_ GEERM 61_ ETPQE 66_ DHLRG 71_ QHYHQ 76_ KGQNG 81_ SFDAP 86_ NERPY 91_ SLKIR 96_ NTTSC 101_ NSGTY 106_ RCTLQ 111_ DPDGQ 116_ RNLSG 121_ KVILR 126_ VTGCP 131_ AQRKE 136_ ETFKK 141_ YRAEI 146_ VLLLA 151_ LVIFY 156_ LTLII 161_ FTCKF 166_ ARLQS 171_ IFPDF 176_ SKAGM 181_ ERAFL 186_ PVTSP 191_ NKHLG 196_LVTPH
1: Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity)