Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)
1_MAAAA 6_ AALSG 11_ AGTPP 16_ AGGGA 21_ GGGGA 26_ GGGGS 31_ PPGGW 36_ AVARL 41_ EGREF 46_ EYLMK 51_ KRSVT 56_ IGRNS 61_ SQGSV 66_ DVSMG 71_ HSSFI 76_ SRRHL 81_ EIFTP 86_ PGGGG 91_ HGGAA 96_ PELPP 101_ AQPRP 106_ DAGGD 111_ FYLRC 116_ LGKNG 121_ VFVDG 126_ VFQRR 131_ GAPPL 136_ QLPRV 141_ CTFRF 146_ PSTNI 151_ KITFT 156_ ALSSE 161_ KREKQ 166_ EASES 171_ PVKAV 176_ QPHIS 181_ PLTIN 186_ IPDTM 191_ AHLIS 196_ PLPSP 201_ TGTIS 206_ AANSC 211_ PSSPR 216_ GAGSS 221_ GYKVG 226_ RVMPS 231_ DLNLM 236_ ADNSQ 241_ PENEK 246_ EASGG 251_ DSPKD 256_ DSKPP 261_ YSYAQ 266_ LIVQA 271_ ITMAP 276_ DKQLT 281_ LNGIY 286_ THITK 291_ NYPYY 296_ RTADK 301_ GWQNS 306_ IRHNL 311_ SLNRY 316_ FIKVP 321_ RSQEE 326_ PGKGS 331_ FWRID 336_ PASES 341_ KLIEQ 346_ AFRKR 351_ RPRGV 356_ PCFRT 361_ PLGPL 366_ SSRSA 371_ PASPN 376_ HAGVL 381_ SAHSS 386_ GAQTP 391_ ESLSR 396_ EGSPA 401_ PLEPE 406_ PGAAQ 411_ PKLAV 416_ IQEAR 421_ FAQSA 426_ PGSPL 431_ SSQPV 436_ LITVQ 441_ RQLPQ 446_ AIKPV 451_ TYTVA 456_ TPVTT 461_ STSQP 466_ PVVQT 471_ VHVVH 476_ QIPAV 481_ SVTSV 486_ AGLAP 491_ ANTYT 496_ VSGQA 501_ VVTPA 506_ AVLAP 511_ PKAEA 516_ QENGD 521_ HREVK 526_ VKVEP 531_ IPAIG 536_ HATLG 541_ TASRI 546_ IQTAQ 551_ TTPVQ 556_ TVTIV 561_ QQAPL 566_ GQHQL 571_ PIKTV 576_ TQNGT 581_ HVASV 586_ PTAVH 591_ GQVNN 596_ AAASP 601_ LHMLA 606_ THASA 611_ SASLP 616_ TKRHN 621_ GDQPE 626_ QPELK 631_ RIKTE 636_ DGEGI 641_ VIALS 646_ VDTPP 651_AAVRE
1: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650)