High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)
1_MDTES 6_ NRRAN 11_ LALPQ 16_ EPSSV 21_ PAFEV 26_ LEISP 31_ QEVSS 36_ GRLLK 41_ SASSP 46_ PLHTW 51_ LTVLK 56_ KEQEF 61_ LGVTQ 66_ ILTAM 71_ ICLCF 76_ GTVVC 81_ SVLDI 86_ SHIEG 91_ DIFSS 96_ FKAGY 101_ PFWGA 106_ IFFSI 111_ SGMLS 116_ IISER 121_ RNATY 126_ LVRGS 131_ LGANT 136_ ASSIA 141_ GGTGI 146_ TILII 151_ NLKKS 156_ LAYIH 161_ IHSCQ 166_ KFFET 171_ KCFMA 176_ SFSTE 181_ IVVMM 186_ LFLTI 191_ LGLGS 196_ AVSLT 201_ ICGAG 206_ EELKG 211_ NKVPE 216_ DRVYE 221_ ELNIY 226_ SATYS 231_ ELEDP 236_GEMSP
1: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy