Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)
1_MATVQ 6_ QLEGR 11_ WRLVD 16_ SKGFD 21_ EYMKE 26_ LGVGI 31_ ALRKM 36_ GAMAK 41_ PDCII 46_ TCDGK 51_ NLTIK 56_ TESTL 61_ KTTQF 66_ SCTLG 71_ EKFEE 76_ TTADG 81_ RKTQT 86_ VCNFT 91_ DGALV 96_ QHQEW 101_ DGKES 106_ TITRK 111_ LKDGK 116_ LVVEC 121_ VMNNV 126_TCTRI
1: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:21395585, PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987)