Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
1_MMNED 6_ AAQKS 11_ DSGEK 16_ FNGSS 21_ QRRKR 26_ PKKSD 31_ SNASF 36_ LRAAR 41_ AGNLD 46_ KVVEY 51_ LKGGI 56_ DINTC 61_ NQNGL 66_ NALHL 71_ AAKEG 76_ HVGLV 81_ QELLG 86_ RGSSV 91_ DSATK 96_ KGNTA 101_ LHIAS 106_ LAGQA 111_ EVVKV 116_ LVKEG 121_ ANINA 126_ QSQNG 131_ FTPLY 136_ MAAQE 141_ NHIDV 146_ VKYLL 151_ ENGAN 156_ QSTAT 161_ EDGFT 166_ PLAVA 171_ LQQGH 176_ NQAVA 181_ ILLEN 186_ DTKGK 191_ VRLPA 196_ LHIAA 201_ RKDDT 206_ KSAAL 211_ LLQND 216_ HNADV 221_ QSKMM 226_ VNRTT 231_ ESGFT 236_ PLHIA 241_ AHYGN 246_ VNVAT 251_ LLLNR 256_ GAAVD 261_ FTARN 266_ GITPL 271_ HVASK 276_ RGNTN 281_ MVKLL 286_ LDRGG 291_ QIDAK 296_ TRDGL 301_ TPLHC 306_ AARSG 311_ HDQVV 316_ ELLLE 321_ RGAPL 326_ LARTK 331_ NGLSP 336_ LHMAA 341_ QGDHV 346_ ECVKH 351_ LLQHK 356_ APVDD 361_ VTLDY 366_ LTALH 371_ VAAHC 376_ GHYRV 381_ TKLLL 386_ DKRAN 391_ PNARA 396_ LNGFT 401_ PLHIA 406_ CKKNR 411_ IKVME 416_ LLVKY 421_ GASIQ 426_ AITES 431_ GLTPI 436_ HVAAF 441_ MGHLN 446_ IVLLL 451_ LQNGA 456_ SPDVT 461_ NIRGE 466_ TALHM 471_ AARAG 476_ QVEVV 481_ RCLLR 486_ NGALV 491_ DARAR 496_ EEQTP 501_ LHIAS 506_ RLGKT 511_ EIVQL 516_ LLQHM 521_ AHPDA 526_ ATTNG 531_ YTPLH 536_ ISARE 541_ GQVDV 546_ ASVLL 551_ EAGAA 556_ HSLAT 561_ KKGFT 566_ PLHVA 571_ AKYGS 576_ LDVAK 581_ LLLQR 586_ RAAAD 591_ SAGKN 596_ GLTPL 601_ HVAAH 606_ YDNQK 611_ VALLL 616_ LEKGA 621_ SPHAT 626_ AKNGY 631_ TPLHI 636_ AAKKN 641_ QMQIA 646_ STLLN 651_ YGAET 656_ NIVTK 661_ QGVTP 666_ LHLAS 671_ QEGHT 676_ DMVTL 681_ LLDKG 686_ ANIHM 691_ STKSG 696_ LTSLH 701_ LAAQE 706_ DKVNV 711_ ADILT 716_ KHGAD 721_ QDAHT 726_ KLGYT 731_ PLIVA 736_ CHYGN 741_ VKMVN 746_ FLLKQ 751_ GANVN 756_ AKTKN 761_ GYTPL 766_ HQAAQ 771_ QGHTH 776_ IINVL 781_ LQHGA 786_ KPNAT 791_ TANGN 796_ TALAI 801_ AKRLG 806_ YISVV 811_ DTLKV 816_ VTEEV 821_ TTTTT 826_ TITEK 831_ HKLNV 836_ PETMT 841_ EVLDV 846_ SDEEG 851_ DDTMT 856_ GDGGE 861_ YLRPE 866_ DLKEL 871_ GDDSL 876_ PSSQF 881_ LDGMN 886_ YLRYS 891_ LEGGR 896_ SDSLR 901_ SFSSD 906_ RSHTL 911_ SHASY 916_ LRDSA 921_ VMDDS 926_ VVIPS 931_ HQVST 936_ LAKEA 941_ ERNSY 946_ RLSWG 951_ TENLD 956_ NVALS 961_ SSPIH 966_ SGFLV 971_ SFMVD 976_ ARGGA 981_ MRGCR 986_ HNGLR 991_ IIIPP 996_ RKCTA 1001_ PTRVT 1006_ CRLVK 1011_ RHRLA 1016_ TMPPM 1021_ VEGEG 1026_ LASRL 1031_ IEVGP 1036_ SGAQF 1041_ LGKLH 1046_ LPTAP 1051_ PPLNE 1056_ GESLV 1061_ SRILQ 1066_ LGPPG 1071_ TKFLG 1076_ PVIVE 1081_ IPHFA 1086_ ALRGK 1091_ ERELV 1096_ VLRSE 1101_ NGDSW 1106_ KEHFC 1111_ DYTED 1116_ ELNEI 1121_ LNGMD 1126_ EVLDS 1131_ PEDLE 1136_ KKRIC 1141_ RIITR 1146_ DFPQY 1151_ FAVVS 1156_ RIKQD 1161_ SNLIG 1166_ PEGGV 1171_ LSSTV 1176_ VPQVQ 1181_ AVFPE 1186_ GALTK 1191_ RIRVG 1196_ LQAQP 1201_ MHSEL 1206_ VKKIL 1211_ GNKAT 1216_ FSPIV 1221_ TLEPR 1226_ RRKFH 1231_ KPITM 1236_ TIPVP 1241_ KASSD 1246_ VMLNG 1251_ FGGDA 1256_ PTLRL 1261_ LCSIT 1266_ GGTTP 1271_ AQWED 1276_ ITGTT 1281_ PLTFV 1286_ NECVS 1291_ FTTNV 1296_ SARFW 1301_ LIDCR 1306_ QIQES 1311_ VTFAS 1316_ QVYRE 1321_ IICVP 1326_ YMAKF 1331_ VVFAK 1336_ SHDPI 1341_ EARLR 1346_ CFCMT 1351_ DDKVD 1356_ KTLEQ 1361_ QENFA 1366_ EVARS 1371_ RDVEV 1376_ LEGKP 1381_ IYVDC 1386_ FGNLV 1391_ PLTKS 1396_ GQHHI 1401_ FSFFA 1406_ FKENR 1411_ LPLFV 1416_ KVRDT 1421_ TQEPC 1426_ GRLSF 1431_ MKEPK 1436_ STRGL 1441_ VHQAI 1446_ CNLNI 1451_ TLPIY 1456_ TKESE 1461_ SDQEQ 1466_ EEEID 1471_ MTSEK 1476_ NDETE 1481_ STETS 1486_ VLKSH 1491_ LVNEV 1496_ PVLAS 1501_ PDLLS 1506_ EVSEM 1511_ KQDLI 1516_ KMTAI 1521_ LTTDV 1526_ SDKAG 1531_ SIKVK 1536_ ELVKA 1541_ AEEEP 1546_ GEPFE 1551_ IVERV 1556_ KEDLE 1561_ KVNEI 1566_ LRSGT 1571_ CTRDE 1576_ SSVQS 1581_ SRSER 1586_ GLVEE 1591_ EWVIV 1596_ SDEEI 1601_ EEARQ 1606_ KAPLE 1611_ ITEYP 1616_ CVEVR 1621_ IDKEI 1626_ KGKVE 1631_ KDSTG 1636_ LVNYL 1641_ TDDLN 1646_ TCVPL 1651_ PKEQL 1656_ QTVQD 1661_ KAGKK 1666_ CEALA 1671_ VGRSS 1676_ EKEGK 1681_ DIPPD 1686_ ETQST 1691_ QKQHK 1696_ PSLGI 1701_ KKPVR 1706_ RKLKE 1711_ KQKQK 1716_ EEGLQ 1721_ ASAEK 1726_ AELKK 1731_ GSSEE 1736_ SLGED 1741_ PGLAP 1746_ EPLPT 1751_ VKATS 1756_ PLIEE 1761_ TPIGS 1766_ IKDKV 1771_ KALQK 1776_ RVEDE 1781_ QKGRS 1786_ KLPIR 1791_ VKGKE 1796_ DVPKK 1801_ TTHRP 1806_ HPAAS 1811_ PSLKS 1816_ ERHAP 1821_ GSPSP 1826_ KTERH 1831_ STLSS 1836_ SAKTE 1841_ RHPPV 1846_ SPSSK 1851_ TEKHS 1856_ PVSPS 1861_ AKTER 1866_ HSPAS 1871_ SSSKT 1876_ EKHSP 1881_ VSPST 1886_ KTERH 1891_ SPVSS 1896_ TKTER 1901_ HPPVS 1906_ PSGKT 1911_ DKRPP 1916_ VSPSG 1921_ RTEKH 1926_ PPVSP 1931_ GRTEK 1936_ RLPVS 1941_ PSGRT 1946_ DKHQP 1951_ VSTAG 1956_ KTEKH 1961_ LPVSP 1966_ SGKTE 1971_ KQPPV 1976_ SPTSK 1981_ TERIE 1986_ ETMSV 1991_ RELMK 1996_ AFQSG 2001_ QDPSK 2006_ HKTGL 2011_ FEHKS 2016_ AKQKQ 2021_ PQEKG 2026_ KVRVE 2031_ KEKGP 2036_ ILTQR 2041_ EAQKT 2046_ ENQTI 2051_ KRGQR 2056_ LPVTG 2061_ TAESK 2066_ RGVRV 2071_ SSIGV 2076_ KKEDA 2081_ AGGKE 2086_ KVLSH 2091_ KIPEP 2096_ VQSVP 2101_ EEESH 2106_ RESEV 2111_ PKEKM 2116_ ADEQG 2121_ DMDLQ 2126_ ISPDR 2131_ KTSTD 2136_ FSEVI 2141_ KQELE 2146_ DNDKY 2151_ QQFRL 2156_ SEETE 2161_ KAQLH 2166_ LDQVL 2171_ TSPFN 2176_ TTFPL 2181_ DYMKD 2186_ EFLPA 2191_ LSLQS 2196_ GALDG 2201_ SSESL 2206_ KNEGV 2211_ AGSPC 2216_ GSLME 2221_ GTPQI 2226_ SSEES 2231_ YKHEG 2236_ LAETP 2241_ ETSPE 2246_ SLSFS 2251_ PKKSE 2256_ EQTGE 2261_ TKEST 2266_ KTETT 2271_ TEIRS 2276_ EKEHP 2281_ TTKDI 2286_ TGGSE 2291_ ERGAT 2296_ VTEDS 2301_ ETSTE 2306_ SFQKE 2311_ ATLGS 2316_ PKDTS 2321_ PKRQD 2326_ DCTGS 2331_ CSVAL 2336_ AKETP 2341_ TGLTE 2346_ EAACD 2351_ EGQRT 2356_ FGSSA 2361_ HKTQT 2366_ DSEVQ 2371_ ESTAT 2376_ SDETK 2381_ ALPLP 2386_ EASVK 2391_ TDTGT 2396_ ESKPQ 2401_ GVIRS 2406_ PQGLE 2411_ LALPS 2416_ RDSEV 2421_ LSAVA 2426_ DDSLA 2431_ VSHKD 2436_ SLEAS 2441_ PVLED 2446_ NSSHK 2451_ TPDSL 2456_ EPSPL 2461_ KESPC 2466_ RDSLE 2471_ SSPVE 2476_ PKMKA 2481_ GIFPS 2486_ HFPLP 2491_ AAVAK 2496_ TELLT 2501_ EVASV 2506_ RSRLL 2511_ RDPDG 2516_ SAEDD 2521_ SLEQT 2526_ SLMES 2531_ SGKSP 2536_ LSPDT 2541_ PSSEE 2546_ VSYEV 2551_ TPKTT 2556_ DVSTP 2561_ KPAVI 2566_ HECAE 2571_ EDDSE 2576_ NGEKK 2581_ RFTPE 2586_ EEMFK 2591_ MVTKI 2596_ KMFDE 2601_ LEQEA 2606_ KQKRD 2611_ YKKEP 2616_ KQEES 2621_ SSSSD 2626_ PDADC 2631_ SVDVD 2636_ EPKHT 2641_ GSGED 2646_ ESGVP 2651_ VLVTS 2656_ ESRKV 2661_ SSSSE 2666_ SEPEL 2671_ AQLKK 2676_ GADSG 2681_ LLPEP 2686_ VIRVQ 2691_ PPSPL 2696_ PSSMD 2701_ SNSSP 2706_ EEVQF 2711_ QPVVS 2716_ KQYTF 2721_ KMNED 2726_ TQEEP 2731_ GKSEE 2736_ EKDSE 2741_ SHLAE 2746_ DRHAV 2751_ STEAE 2756_ DRSYD 2761_ KLNRD 2766_ TDQPK 2771_ ICDGH 2776_ GCEAM 2781_ SPSSS 2786_ AAPVS 2791_ SGLQS 2796_ PTGDD 2801_ VDEQP 2806_ VIYKE 2811_ SLALQ 2816_ GTHEK 2821_ DTEGE 2826_ ELDVS 2831_ RAESP 2836_ QADCP 2841_ SESFS 2846_ SSSSL 2851_ PHCLV 2856_ SEGKE 2861_ LDEDI 2866_ SATSS 2871_ IQKTE 2876_ VTKTD 2881_ ETFEN 2886_ LPKDC 2891_ PSQDS 2896_ SITTQ 2901_ TDRFS 2906_ MDVPV 2911_ SDLAE 2916_ NDEIY 2921_ DPQIT 2926_ SPYEN 2931_ VPSQS 2936_ FFSSE 2941_ ESKTQ 2946_ TDANH 2951_ TTSFH 2956_ SSEVY 2961_ SVTIT 2966_ SPVED 2971_ VVVAS 2976_ SSSGT 2981_ VLSKE 2986_ SNFEG 2991_ QDIKM 2996_ ESQQE 3001_ STLWE 3006_ MQSDS 3011_ VSSSF 3016_ EPTMS 3021_ ATTTV 3026_ VGEQI 3031_ SKVII 3036_ TKTDV 3041_ DSDSW 3046_ SEIRE 3051_ DDEAF 3056_ EARVK 3061_ EEEQK 3066_ IFGLM 3071_ VDRQS 3076_ QGTTP 3081_ DTTPA 3086_ RTPTE 3091_ EGTPT 3096_ SEQNP 3101_ FLFQE 3106_ GKLFE 3111_ MTRSG 3116_ AIDMT 3121_ KRSYA 3126_ DESFH 3131_ FFQIG 3136_ QESRE 3141_ ETLSE 3146_ DVKEG 3151_ ATGAD 3156_ PLPLE 3161_ TSAES 3166_ LALSE 3171_ SKETV 3176_ DDEAD 3181_ LLPDD 3186_ VSEEV 3191_ EEIPA 3196_ SDAQL 3201_ NSQMG 3206_ ISAST 3211_ ETPTK 3216_ EAVSV 3221_ GTKDL 3226_ PTVQT 3231_ GDIPP 3236_ LSGVK 3241_ QISCP 3246_ DSSEP 3251_ AVQVQ 3256_ LDFST 3261_ LTRSV 3266_ YSDRG 3271_ DDSPD 3276_ SSPEE 3281_ QKSVI 3286_ EIPTA 3291_ PMENV 3296_ PFTES 3301_ KSKIP 3306_ VRTMP 3311_ TSTPA 3316_ PPSAE 3321_ YESSV 3326_ SEDFL 3331_ SSVDE 3336_ ENKAD 3341_ EAKPK 3346_ SKLPV 3351_ KVPLQ 3356_ RVEQQ 3361_ LSDLD 3366_ TSVQK 3371_ TVAPQ 3376_ GQDMA 3381_ SIAPD 3386_ NRSKS 3391_ ESDAS 3396_ SLDSK 3401_ TKCPV 3406_ KTRSY 3411_ TETET 3416_ ESRER 3421_ AEELE 3426_ LESEE 3431_ GATRP 3436_ KILTS 3441_ RLPVK 3446_ SRSTT 3451_ SSCRG 3456_ GTSPT 3461_ KESKE 3466_ HFFDL 3471_ YRNSI 3476_ EFFEE 3481_ ISDEA 3486_ SKLVD 3491_ RLTQS 3496_ EREQE 3501_ IVSDD 3506_ ESSSA 3511_ LEVSV 3516_ IENLP 3521_ PVETE 3526_ HSVPE 3531_ DIFDT 3536_ RPIWD 3541_ ESIET 3546_ LIERI 3551_ PDENG 3556_ HDHAE 3561_ DPQDE 3566_ QERIE 3571_ ERLAY 3576_ IADHL 3581_ GFSWT 3586_ ELARE 3591_ LDFTE 3596_ EQIHQ 3601_ IRIEN 3606_ PNSLQ 3611_ DQSHA 3616_ LLKYW 3621_ LERDG 3626_ KHATD 3631_ TNLVE 3636_ CLTKI 3641_ NRMDI 3646_ VHLME 3651_ TNTEP 3656_ LQERI 3661_ SHSYA 3666_ EIEQT 3671_ ITLDH 3676_ SEGFS 3681_ VLQEE 3686_ LCTAQ 3691_ HKQKE 3696_ EQAVS 3701_ KESET 3706_ CDHPP 3711_ IVSEE 3716_ DISVG 3721_ YSTFQ 3726_ DGVPK 3731_ TEGDS 3736_ SATAL 3741_ FPQTH 3746_ KEQVQ 3751_ QDFSG 3756_ KMQDL 3761_ PEESS 3766_ LEYQQ 3771_ EYFVT 3776_ TPGTE 3781_ TSETQ 3786_ KAMIV 3791_ PSSPS 3796_ KTPEE 3801_ VSTPA 3806_ EEEKL 3811_ YLQTP 3816_ TSSER 3821_ GGSPI 3826_ IQEPE 3831_ EPSEH 3836_ REESS 3841_ PRKTS 3846_ LVIVE 3851_ SADNQ 3856_ PETCE 3861_ RLDED 3866_ AAFEK 3871_ GDDMP 3876_ EIPPE 3881_ TVTEE 3886_ EYIDE 3891_ HGHTV 3896_ VKKVT 3901_ RKIIR 3906_ RYVSS 3911_ EGTEK 3916_ EEIMV 3921_ QGMPQ 3926_ EPVNI 3931_ EEGDG 3936_ YSKVI 3941_ KRVVL 3946_ KSDTE 3951_QSEDN
1: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity)