Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
1_MPGSL 6_ PLNAE 11_ ACWPK 16_ DVGIV 21_ ALEIY 26_ FPSQY 31_ VDQAE 36_ LEKYD 41_ GVDAG 46_ KYTIG 51_ LGQAK 56_ MGFCT 61_ DREDI 66_ NSLCM 71_ TVVQN 76_ LMERN 81_ NLSYD 86_ CIGRL 91_ EVGTE 96_ TIIDK 101_ SKSVK 106_ TNLMQ 111_ LFEES 116_ GNTDI 121_ EGIDT 126_ TNACY 131_ GGTAA 136_ VFNAV 141_ NWIES 146_ SSWDG 151_ RYALV 156_ VAGDI 161_ AVYAT 166_ GNARP 171_ TGGVG 176_ AVALL 181_ IGPNA 186_ PLIFE 191_ RGLRG 196_ THMQH 201_ AYDFY 206_ KPDML 211_ SEYPI 216_ VDGKL 221_ SIQCY 226_ LSALD 231_ RCYSV 236_ YCKKI 241_ HAQWQ 246_ KEGND 251_ KDFTL 256_ NDFGF 261_ MIFHS 266_ PYCKL 271_ VQKSL 276_ ARMLL 281_ NDFLN 286_ DQNRD 291_ KNSIY 296_ SGLEA 301_ FGDVK 306_ LEDTY 311_ FDRDV 316_ EKAFM 321_ KASSE 326_ LFSQK 331_ TKASL 336_ LVSNQ 341_ NGNMY 346_ TSSVY 351_ GSLAS 356_ VLAQY 361_ SPQQL 366_ AGKRI 371_ GVFSY 376_ GSGLA 381_ ATLYS 386_ LKVTQ 391_ DATPG 396_ SALDK 401_ ITASL 406_ CDLKS 411_ RLDSR 416_ TGVAP 421_ DVFAE 426_ NMKLR 431_ EDTHH 436_ LVNYI 441_ PQGSI 446_ DSLFE 451_ GTWYL 456_ VRVDE 461_ KHRRT 466_ YARRP 471_ TPNDD 476_ TLDEG 481_ VGLVH 486_ SNIAT 491_ EHIPS 496_ PAKKV 501_ PRLPA 506_ TAAEP 511_EAAVI
1: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis