Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)
1_MGFWI 6_ LAILT 11_ ILMYS 16_ TAAKF 21_ SKQSW 26_ GLENE 31_ ALIVR 36_ CPRQG 41_ KPSYT 46_ VDWYY 51_ SQTNK 56_ SIPTQ 61_ ERNRV 66_ FASGQ 71_ LLKFL 76_ PAAVA 81_ DSGIY 86_ TCIVR 91_ SPTFN 96_ RTGYA 101_ NVTIY 106_ KKQSD 111_ CNVPD 116_ YLMYS 121_ TVSGS 126_ EKNSK 131_ IYCPT 136_ IDLYN 141_ WTAPL 146_ EWFKN 151_ CQALQ 156_ GSRYR 161_ AHKSF 166_ LVIDN 171_ VMTED 176_ AGDYT 181_ CKFIH 186_ NENGA 191_ NYSVT 196_ ATRSF 201_ TVKDE 206_ QGFSL 211_ FPVIG 216_ APAQN 221_ EIKEV 226_ EIGKN 231_ ANLTC 236_ SACFG 241_ KGTQF 246_ LAAVL 251_ WQLNG 256_ TKITD 261_ FGEPR 266_ IQQEE 271_ GQNQS 276_ FSNGL 281_ ACLDM 286_ VLRIA 291_ DVKEE 296_ DLLLQ 301_ YDCLA 306_ LNLHG 311_ LRRHT 316_ VRLSR 321_ KNPID 326_ HHSIY 331_ CIIAV 336_ CSVFL 341_ MLINV 346_ LVIIL 351_ KMFWI 356_ EATLL 361_ WRDIA 366_ KPYKT 371_ RNDGK 376_ LYDAY 381_ VVYPR 386_ NYKSS 391_ TDGAS 396_ RVEHF 401_ VHQIL 406_ PDVLE 411_ NKCGY 416_ TLCIY 421_ GRDML 426_ PGEDV 431_ VTAVE 436_ TNIRK 441_ SRRHI 446_ FILTP 451_ QITHN 456_ KEFAY 461_ EQEVA 466_ LHCAL 471_ IQNDA 476_ KVILI 481_ EMEAL 486_ SELDM 491_ LQAEA 496_ LQDSL 501_ QHLMK 506_ VQGTI 511_ KWRED 516_ HIANK 521_ RSLNS 526_ KFWKH 531_ VRYQM 536_ PVPSK 541_ IPRKA 546_ SSLTP 551_LAAQK
1: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity)
2: Inhibits IL-33 signaling