Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
1_MAGAG 6_ PKRRA 11_ LAAPA 16_ AEEKE 21_ EAREK 26_ MLAAK 31_ SADGS 36_ APAGE 41_ GEGVT 46_ LQRNI 51_ TLLNG 56_ VAIIV 61_ GTIIG 66_ SGIFV 71_ TPTGV 76_ LKEAG 81_ SPGLA 86_ LVVWA 91_ ACGVF 96_ SIVGA 101_ LCYAE 106_ LGTTI 111_ SKSGG 116_ DYAYM 121_ LEVYG 126_ SLPAF 131_ LKLWI 136_ ELLII 141_ RPSSQ 146_ YIVAL 151_ VFATY 156_ LLKPL 161_ FPTCP 166_ VPEEA 171_ AKLVA 176_ CLCVL 181_ LLTAV 186_ NCYSV 191_ KAATR 196_ VQDAF 201_ AAAKL 206_ LALAL 211_ IILLG 216_ FVQIG 221_ KGDVS 226_ NLDPN 231_ FSFEG 236_ TKLDV 241_ GNIVL 246_ ALYSG 251_ LFAYG 256_ GWNYL 261_ NFVTE 266_ EMINP 271_ YRNLP 276_ LAIII 281_ SLPIV 286_ TLVYV 291_ LTNLA 296_ YFTTL 301_ STEQM 306_ LSSEA 311_ VAVDF 316_ GNYHL 321_ GVMSW 326_ IIPVF 331_ VGLSC 336_ FGSVN 341_ GSLFT 346_ SSRLF 351_ FVGSR 356_ EGHLP 361_ SILSM 366_ IHPQL 371_ LTPVP 376_ SLVFT 381_ CVMTL 386_ LYAFS 391_ KDIFS 396_ VINFF 401_ SFFNW 406_ LCVAL 411_ AIIGM 416_ IWLRH 421_ RKPEL 426_ ERPIK 431_ VNLAL 436_ PVFFI 441_ LACLF 446_ LIAVS 451_ FWKTP 456_ VECGI 461_ GFTII 466_ LSGLP 471_ VYFFG 476_ VWWKN 481_ KPKWL 486_ LQGIF 491_ STTVL 496_ CQKLM 501_QVVPQ
1: The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine (PubMed:10049700, PubMed:10574970, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591, PubMed:9751058). The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744)
2: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis