Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)
1_MASSS 6_ GNDDD 11_ LTIPR 16_ AAINK 21_ MIKET 26_ LPNVR 31_ VANDA 36_ RELVV 41_ NCCTE 46_ FIHLI 51_ SSEAN 56_ EICNK 61_ SEKKT 66_ ISPEH 71_ VIQAL 76_ ESLGF 81_ GSYIS 86_ EVKEV 91_ LQECK 96_ TVALK 101_ RRKAS 106_ SRLEN 111_ LGIPE 116_ EELLR 121_ QQQEL 126_ FAKAR 131_ QQQAE 136_ LAQQE 141_ WLQMQ 146_ QAAQQ 151_ AQLAA 156_ ASASA 161_ SNQAG 166_ SSQDE 171_EDDDD
1: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4