Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
1_MKHII 6_ NSYEN 11_ INNTA 16_ RNNSD 21_ CPRVV 26_ LPEEI 31_ FFTIS 36_ IVGVL 41_ ENLIV 46_ LLAVF 51_ KNKNL 56_ QAPMY 61_ FFICS 66_ LAISD 71_ MLGSL 76_ YKILE 81_ NILII 86_ LRNMG 91_ YLKPR 96_ GSFET 101_ TADDI 106_ IDSLF 111_ VLSLL 116_ GSIFS 121_ LSVIA 126_ ADRYI 131_ TIFHA 136_ LRYHS 141_ IVTMR 146_ RTVVV 151_ LTVIW 156_ TFCTG 161_ TGITM 166_ VIFSH 171_ HVPTV 176_ ITFTS 181_ LFPLM 186_ LVFIL 191_ CLYVH 196_ MFLLA 201_ RSHTR 206_ KISTL 211_ PRANM 216_ KGAIT 221_ LTILL 226_ GVFIF 231_ CWAPF 236_ VLHVL 241_ LMTFC 246_ PSNPY 251_ CACYM 256_ SLFQV 261_ NGMLI 266_ MCNAV 271_ IDPFI 276_ YAFRS 281_ PELRD 286_ AFKKM 291_IFCSR
1: Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function (PubMed:36588120). Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity). Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (By similarity)