Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)
1_MAVQG 6_ SQRRL 11_ LGSLN 16_ STPTA 21_ IPQLG 26_ LAANQ 31_ TGARC 36_ LEVSI 41_ SDGLF 46_ LSLGL 51_ VSLVE 56_ NALVV 61_ ATIAK 66_ NRNLH 71_ SPMYC 76_ FICCL 81_ ALSDL 86_ LVSGS 91_ NVLET 96_ AVILL 101_ LEAGA 106_ LVARA 111_ AVLQQ 116_ LDNVI 121_ DVITC 126_ SSMLS 131_ SLCFL 136_ GAIAV 141_ DRYIS 146_ IFYAL 151_ RYHSI 156_ VTLPR 161_ ARRAV 166_ AAIWV 171_ ASVVF 176_ STLFI 181_ AYYDH 186_ VAVLL 191_ CLVVF 196_ FLAML 201_ VLMAV 206_ LYVHM 211_ LARAC 216_ QHAQG 221_ IARLH 226_ KRQRP 231_ VHQGF 236_ GLKGA 241_ VTLTI 246_ LLGIF 251_ FLCWG 256_ PFFLH 261_ LTLIV 266_ LCPEH 271_ PTCGC 276_ IFKNF 281_ NLFLA 286_ LIICN 291_ AIIDP 296_ LIYAF 301_ HSQEL 306_ RRTLK 311_EVLTC
1: Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585)