Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1)
1_MAKRV 6_ AIVGA 11_ GVSGL 16_ ASIKC 21_ CLEEG 26_ LEPTC 31_ FERSD 36_ DLGGL 41_ WRFTE 46_ HVEEG 51_ RASLY 56_ KSVVS 61_ NSCKE 66_ MSCYS 71_ DFPFP 76_ EDYPN 81_ YVPNS 86_ QFLEY 91_ LKMYA 96_ NHFDL 101_ LKHIQ 106_ FKTKV 111_ CSVTK 116_ CSDSA 121_ VSGQW 126_ EVVTM 131_ HEEKQ 136_ ESAIF 141_ DAVMV 146_ CTGFL 151_ TNPYL 156_ PLDSF 161_ PGINA 166_ FKGQY 171_ FHSRQ 176_ YKHPD 181_ IFKDK 186_ RVLVI 191_ GMGNS 196_ GTDIA 201_ VEASH 206_ LAEKV 211_ FLSTT 216_ GGGWV 221_ ISRIF 226_ DSGYP 231_ WDMVF 236_ MTRFQ 241_ NMLRN 246_ SLPTP 251_ IVTWL 256_ MERKI 261_ NNWLN 266_ HANYG 271_ LIPED 276_ RTQLK 281_ EFVLN 286_ DELPG 291_ RIITG 296_ KVFIR 301_ PSIKE 306_ VKENS 311_ VIFNN 316_ TSKEE 321_ PIDII 326_ VFATG 331_ YTFAF 336_ PFLDE 341_ SVVKV 346_ EDGQA 351_ SLYKY 356_ IFPAH 361_ LQKPT 366_ LAIIG 371_ LIKPL 376_ GSMIP 381_ TGETQ 386_ ARWAV 391_ RVLKG 396_ VNKLP 401_ PPSVM 406_ IEEIN 411_ ARKEN 416_ KPSWF 421_ GLCYC 426_ KALQS 431_ DYITY 436_ IDELL 441_ TYINA 446_ KPNLF 451_ SMLLT 456_ DPHLA 461_ LTVFF 466_ GPCSP 471_ YQFRL 476_ TGPGK 481_ WEGAR 486_ NAIMT 491_ QWDRT 496_ FKVIK 501_ ARVVQ 506_ ESPSP 511_ FESFL 516_ KVFSF 521_ LALLV 526_AIFLI
1: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:32156684). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (PubMed:32156684). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity)