OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)
1_MEAAV 6_ GVPDG 11_ GDQGG 16_ AGPRE 21_ DATPM 26_ DAYLR 31_ KLGLY 36_ RKLVA 41_ KDGSC 46_ LFRAV 51_ AEQVL 56_ HSQSR 61_ HVEVR 66_ MACIH 71_ YLREN 76_ REKFE 81_ AFIEG 86_ SFEEY 91_ LKRLE 96_ NPQEW 101_ VGQVE 106_ ISALS 111_ LMYRK 116_ DFIIY 121_ REPNV 126_ SPSQV 131_ TENNF 136_ PEKVL 141_ LCFSN 146_ GNHYD 151_ IVYPI 156_ KYKES 161_ SAMCQ 166_ SLLYE 171_ LLYEK 176_ VFKTD 181_ VSKIV 186_ MELDT 191_ LEVAD 196_ EDNSE 201_ ISDSE 206_ DDSCK 211_ SKTAA 216_ AAADV 221_ NGFKP 226_ LSGNE 231_ QLKNN 236_ GNSTS 241_ LPLSR 246_ KVLKS 251_ LNPAV 256_ YRNVE 261_ YEIWL 266_ KSKQA 271_ QQKRD 276_ YSIAA 281_ GLQYE 286_ VGDKC 291_ QVRLD 296_ HNGKF 301_ LNADV 306_ QGIHS 311_ ENGPV 316_ LVEEL 321_ GKKHT 326_ SKNLK 331_ APPPE 336_ SWNTV 341_ SGKKM 346_ KKPST 351_ SGQNF 356_ HSDVD 361_ YRGPK 366_ NPSKP 371_ IKAPS 376_ ALPPR 381_ LQHPS 386_ GVRQH 391_ AFSSH 396_ SSGSQ 401_ SQKFS 406_ SEHKN 411_ LSRTP 416_ SQIIR 421_ KPDRE 426_ RVEDF 431_ DHTSR 436_ ESNYF 441_ GLSPE 446_ ERREK 451_ QAIEE 456_ SRLLY 461_ EIQNR 466_ DEQAF 471_ PALSS 476_ SSVNQ 481_ SASQS 486_ SNPCV 491_ QRKSS 496_ HVGDR 501_ KGSRR 506_ RMDTE 511_ ERKDK 516_ DSIHG 521_ HSQLD 526_ KRPEP 531_ STLEN 536_ ITDDK 541_ YATVS 546_ SPSKS 551_ KKLEC 556_ PSPAE 561_ QKPAE 566_ HVSLS 571_ NPAPL 576_ LVSPE 581_ VHLTP 586_ AVPSL 591_ PATVP 596_ AWPSE 601_ PTTFG 606_ PTGVP 611_ APIPV 616_ LSVTQ 621_ TLTTG 626_ PDSAV 631_ SQAHL 636_ TPSPV 641_ PVSIQ 646_ AVNQP 651_ LMPLP 656_ QTLSL 661_ YQDPL 666_ YPGFP 671_ CNEKG 676_ DRAIV 681_ PPYSL 686_ CQTGE 691_ DLPKD 696_ KNILR 701_ FFFNL 706_ GVKAY 711_ SCPMW 716_ APHSY 721_ LYPLH 726_ QAYLA 731_ ACRMY 736_ PKVPV 741_ PVYPH 746_ NPWFQ 751_ EAPAA 756_ QNESD 761_ CTCTD 766_ AHFPM 771_ QTEAS 776_ VNGQM 781_ PQPEI 786_ GPPTF 791_ SSPLV 796_ IPPSQ 801_ VSESH 806_ GQLSY 811_ QADLE 816_ SETPG 821_ QLLHA 826_ DYEES 831_ LSGKN 836_ MFPQP 841_ SFGPN 846_ PFLGP 851_ VPIAP 856_ PFFPH 861_ VWYGY 866_ PFQGF 871_ IENPV 876_ MRQNI 881_ VLPSD 886_ EKGEL 891_ DLSLE 896_ NLDLS 901_ KDCGS 906_ VSTVD 911_ EFPEA 916_ RGEHV 921_ HSLPE 926_ ASVSS 931_ KPDEG 936_ RTEQS 941_ SQTRK 946_ ADTAL 951_ ASIPP 956_ VAEGK 961_ AHPPT 966_ QILNR 971_ ERETV 976_ PVELE 981_ PKRTI 986_ QSLKE 991_ KTEKV 996_ KDPKT 1001_ AADVV 1006_ SPGAN 1011_ SVDSR 1016_ VQRPK 1021_ EESSE 1026_ DENEV 1031_ SNILR 1036_ SGRSK 1041_ QFYNQ 1046_ TYGSR 1051_ KYKSD 1056_ WGYSG 1061_ RGGYQ 1066_ HVRSE 1071_ ESWKG 1076_ QPSRS 1081_ RDEGY 1086_ QYHRN 1091_ VRGRP 1096_ FRGDR 1101_ RRSGM 1106_GDGHR
1: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111)