Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
1_MGDMT 6_ NSDFY 11_ SKNQR 16_ NESSH 21_ GGEFG 26_ CTMEE 31_ LRSLM 36_ ELRGT 41_ EAVVK 46_ IKETY 51_ GDTEA 56_ ICRRL 61_ KTSPV 66_ EGLPG 71_ TAPDL 76_ EKRKQ 81_ IFGQN 86_ FIPPK 91_ KPKTF 96_ LQLVW 101_ EALQD 106_ VTLII 111_ LEIAA 116_ IISLG 121_ LSFYH 126_ PPGEG 131_ NEGCA 136_ TAQGG 141_ AEDEG 146_ EAEAG 151_ WIEGA 156_ AILLS 161_ VICVV 166_ LVTAF 171_ NDWSK 176_ EKQFR 181_ GLQSR 186_ IEQEQ 191_ KFTVV 196_ RAGQV 201_ VQIPV 206_ AEIVV 211_ GDIAQ 216_ VKYGD 221_ LLPAD 226_ GLFIQ 231_ GNDLK 236_ IDESS 241_ LTGES 246_ DQVRK 251_ SVDKD 256_ PMLLS 261_ GTHVM 266_ EGSGR 271_ MLVTA 276_ VGVNS 281_ QTGII 286_ FTLLG 291_ AGGEE 296_ EEKKD 301_ KKGVK 306_ KGDGL 311_ QLPAA 316_ DGAAA 321_ SNAAD 326_ SANAS 331_ LVNGK 336_ MQDGN 341_ VDASQ 346_ SKAKQ 351_ QDGAA 356_ AMEMQ 361_ PLKSA 366_ EGGDA 371_ DDRKK 376_ ASMHK 381_ KEKSV 386_ LQGKL 391_ TKLAV 396_ QIGKA 401_ GLVMS 406_ AITVI 411_ ILVLY 416_ FTVDT 421_ FVVNK 426_ KPWLP 431_ ECTPV 436_ YVQYF 441_ VKFFI 446_ IGVTV 451_ LVVAV 456_ PEGLP 461_ LAVTI 466_ SLAYS 471_ VKKMM 476_ KDNNL 481_ VRHLD 486_ ACETM 491_ GNATA 496_ ICSDK 501_ TGTLT 506_ TNRMT 511_ VVQAY 516_ VGDVH 521_ YKEIP 526_ DPSSI 531_ NTKTM 536_ ELLIN 541_ AIAIN 546_ SAYTT 551_ KILPP 556_ EKEGA 561_ LPRQV 566_ GNKTE 571_ CGLLG 576_ FVLDL 581_ KQDYE 586_ PVRSQ 591_ MPEEK 596_ LYKVY 601_ TFNSV 606_ RKSMS 611_ TVIKL 616_ PDESF 621_ RMYSK 626_ GASEI 631_ VLKKC 636_ CKILN 641_ GAGEP 646_ RVFRP 651_ RDRDE 656_ MVKKV 661_ IEPMA 666_ CDGLR 671_ TICVA 676_ YRDFP 681_ SSPEP 686_ DWDNE 691_ NDILN 696_ ELTCI 701_ CVVGI 706_ EDPVR 711_ PEVPE 716_ AIRKC 721_ QRAGI 726_ TVRMV 731_ TGDNI 736_ NTARA 741_ IAIKC 746_ GIIHP 751_ GEDFL 756_ CLEGK 761_ EFNRR 766_ IRNEK 771_ GEIEQ 776_ ERIDK 781_ IWPKL 786_ RVLAR 791_ SSPTD 796_ KHTLV 801_ KGIID 806_ STHTE 811_ QRQVV 816_ AVTGD 821_ GTNDG 826_ PALKK 831_ ADVGF 836_ AMGIA 841_ GTDVA 846_ KEASD 851_ IILTD 856_ DNFSS 861_ IVKAV 866_ MWGRN 871_ VYDSI 876_ SKFLQ 881_ FQLTV 886_ NVVAV 891_ IVAFT 896_ GACIT 901_ QDSPL 906_ KAVQM 911_ LWVNL 916_ IMDTF 921_ ASLAL 926_ ATEPP 931_ TETLL 936_ LRKPY 941_ GRNKP 946_ LISRT 951_ MMKNI 956_ LGHAV 961_ YQLAL 966_ IFTLL 971_ FVGEK 976_ MFQID 981_ SGRNA 986_ PLHSP 991_ PSEHY 996_ TIIFN 1001_ TFVMM 1006_ QLFNE 1011_ INARK 1016_ IHGER 1021_ NVFDG 1026_ IFRNP 1031_ IFCTI 1036_ VLGTF 1041_ AIQIV 1046_ IVQFG 1051_ GKPFS 1056_ CSPLQ 1061_ LDQWM 1066_ WCIFI 1071_ GLGEL 1076_ VWGQV 1081_ IATIP 1086_ TSRLK 1091_ FLKEA 1096_ GRLTQ 1101_ KEEIP 1106_ EEELN 1111_ EDVEE 1116_ IDHAE 1121_ RELRR 1126_ GQILW 1131_ FRGLN 1136_ RIQTQ 1141_ IRVVK 1146_ AFRSS 1151_ LYEGL 1156_ EKPES 1161_ RTSIH 1166_ NFMAH 1171_ PEFRI 1176_ EDSQP 1181_ HIPLI 1186_ DDTDL 1191_ EEDAA 1196_ LKQNS 1201_ SPPSS 1206_ LNKNN 1211_ SAIDS 1216_ GINLT 1221_ TDTSK 1226_ SATSS 1231_ SPGSP 1236_IHSLE
1: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity)