RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
1_MASTD 6_ YSTYS 11_ QAAAQ 16_ QGYSA 21_ YTAQP 26_ TQGYA 31_ QTTQA 36_ YGQQS 41_ YGTYG 46_ QPTDV 51_ SYTQA 56_ QTTAT 61_ YGQTA 66_ YATSY 71_ GQPPT 76_ GYTTP 81_ TAPQA 86_ YSQPV 91_ QGYGT 96_ GAYDT 101_ TTATV 106_ TTTQA 111_ SYAAQ 116_ SAYGT 121_ QPAYP 126_ AYGQQ 131_ PAATA 136_ PTRPQ 141_ DGNKP 146_ TETSQ 151_ PQSST 156_ GGYNQ 161_ PSLGY 166_ GQSNY 171_ SYPQV 176_ PGSYP 181_ MQPVT 186_ APPSY 191_ PPTSY 196_ SSTQP 201_ TSYDQ 206_ SSYSQ 211_ QNTYG 216_ QPSSY 221_ GQQSS 226_ YGQQS 231_ SYGQQ 236_ PPTSY 241_ PPQTG 246_ SYSQA 251_ PSQYS 256_ QQSSS 261_ YGQQS 266_ SFRQD 271_ HPSSM 276_ GVYGQ 281_ ESGGF 286_ SGPGE 291_ NRSMS 296_ GPDNR 301_ GRGRG 306_ GFDRG 311_ GMSRG 316_ GRGGG 321_ RGGMG 326_ SAGER 331_ GGFNK 336_ PGGPM 341_ DEGPD 346_ LDLGP 351_ PVDPD 356_ EDSDN 361_ SAIYV 366_ QGLND 371_ SVTLD 376_ DLADF 381_ FKQCG 386_ VVKMN 391_ KRTGQ 396_ PMIHI 401_ YLDKE 406_ TGKPK 411_ GDATV 416_ SYEDP 421_ PTAKA 426_ AVEWF 431_ DGKDF 436_ QGSKL 441_ KVSLA 446_ RKKPP 451_ MNSMR 456_ GGLPP 461_ REGRG 466_ MPPPL 471_ RGGPG 476_ GPGGP 481_ GGPMG 486_ RMGGR 491_ GGDRG 496_ GFPPR 501_ GPRGS 506_ RGNPS 511_ GGGNV 516_ QHRAG 521_ DWQCP 526_ NPGCG 531_ NQNFA 536_ WRTEC 541_ NQCKA 546_ PKPEG 551_ FLPPP 556_ FPPPG 561_ GDRGR 566_ GGPGG 571_ MRGGR 576_ GGLMD 581_ RGGPG 586_ GMFRG 591_ GRGGD 596_ RGGFR 601_ GGRGM 606_ DRGGF 611_ GGGRR 616_ GGPGG 621_ PPGPL 626_ MEQMG 631_ GRRGG 636_ RGGPG 641_ KMDKG 646_ EHRQE 651_RRDRP
1: Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes