POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)
1_MAGHL 6_ ASDFA 11_ FSPPP 16_ GGGGD 21_ GPGGP 26_ EPGWV 31_ DPRTW 36_ LSFQG 41_ PPGGP 46_ GIGPG 51_ VGPGS 56_ EVWGI 61_ PPCPP 66_ PYEFC 71_ GGMAY 76_ CGPQV 81_ GVGLV 86_ PQGGL 91_ ETSQP 96_ EGEAG 101_ VGVES 106_ NSDGA 111_ SPEPC 116_ TVTPG 121_ AVKLE 126_ KEKLE 131_ QNPEE 136_ SQDIK 141_ ALQKE 146_ LEQFA 151_ KLLKQ 156_ KRITL 161_ GYTQA 166_ DVGLT 171_ LGVLF 176_ GKVFS 181_ QTTIC 186_ RFEAL 191_ QLSFK 196_ NMCKL 201_ RPLLQ 206_ KWVEE 211_ ADNNE 216_ NLQEI 221_ CKAET 226_ LVQAR 231_ KRKRT 236_ SIENR 241_ VRGNL 246_ ENLFL 251_ QCPKP 256_ TLQQI 261_ SHIAQ 266_ QLGLE 271_ KDVVR 276_ VWFCN 281_ RRQKG 286_ KRSSS 291_ DYAQR 296_ EDFEA 301_ AGSPF 306_ SGGPV 311_ SFPLA 316_ PGPHF 321_ GTPGY 326_ GSPHF 331_ TALYS 336_ SVPFP 341_ EGEAF 346_ PPVSV 351_TTLGS
1: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency