Transcription factor Spi-B
1_MLALE 6_ AAQLD 11_ GPHFS 16_ CLYPD 21_ GVFYD 26_ LDSCK 31_ HSSYP 36_ DSEGA 41_ PDSLW 46_ DWTVA 51_ PPVPA 56_ TPYEA 61_ FDPAA 66_ AAFSH 71_ PQAAQ 76_ LCYEP 81_ PTYSP 86_ AGNLE 91_ LAPSL 96_ EAPGP 101_ GLPAY 106_ PTENF 111_ ASQTL 116_ VPPAY 121_ APYPS 126_ PVLSE 131_ EEDLP 136_ LDSPA 141_ LEVSD 146_ SESDE 151_ ALVAG 156_ PEGKG 161_ SEAGT 166_ RKKLR 171_ LYQFL 176_ LGLLT 181_ RGDMR 186_ ECVWW 191_ VEPGA 196_ GVFQF 201_ SSKHK 206_ ELLAR 211_ RWGQQ 216_ KGNRK 221_ RMTYQ 226_ KLARA 231_ LRNYA 236_ KTGEI 241_ RKVKR 246_ KLTYQ 251_ FDSAL 256_LPAVR
1: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation