Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin]
1_MSART 6_ APRPQ 11_ VLLLP 16_ LLLVL 21_ LAAAP 26_ AASKG 31_ CVCKD 36_ KGQCF 41_ CDGAK 46_ GEKGE 51_ KGFPG 56_ PPGSP 61_ GQKGF 66_ TGPEG 71_ LPGPQ 76_ GPKGF 81_ PGLPG 86_ LTGSK 91_ GVRGI 96_ SGLPG 101_ FSGSP 106_ GLPGT 111_ PGNTG 116_ PYGLV 121_ GVPGC 126_ SGSKG 131_ EQGFP 136_ GLPGT 141_ LGYPG 146_ IPGAA 151_ GLKGQ 156_ KGAPA 161_ KEEDI 166_ ELDAK 171_ GDPGL 176_ PGAPG 181_ PQGLP 186_ GPPGF 191_ PGPVG 196_ PPGPP 201_ GFFGF 206_ PGAMG 211_ PRGPK 216_ GHMGE 221_ RVIGH 226_ KGERG 231_ VKGLT 236_ GPPGP 241_ PGTVI 246_ VTLTG 251_ PDNRT 256_ DLKGE 261_ KGDKG 266_ AMGEP 271_ GPPGP 276_ SGLPG 281_ ESYGS 286_ EKGAP 291_ GDPGL 296_ QGKPG 301_ KDGVP 306_ GFPGS 311_ EGVKG 316_ NRGFP 321_ GLMGE 326_ DGIKG 331_ QKGDI 336_ GPPGF 341_ RGPTE 346_ YYDTY 351_ QEKGD 356_ EGTPG 361_ PPGPR 366_ GARGP 371_ QGPSG 376_ PPGVP 381_ GSPGS 386_ SRPGL 391_ RGAPG 396_ WPGLK 401_ GSKGE 406_ RGRPG 411_ KDAMG 416_ TPGSP 421_ GCAGS 426_ PGLPG 431_ SPGPP 436_ GPPGD 441_ IVFRK 446_ GPPGD 451_ HGLPG 456_ YLGSP 461_ GIPGV 466_ DGPKG 471_ EPGLL 476_ CTQCP 481_ YIPGP 486_ PGLPG 491_ LPGLH 496_ GVKGI 501_ PGRQG 506_ AAGLK 511_ GSPGS 516_ PGNTG 521_ LPGFP 526_ GFPGA 531_ QGDPG 536_ LKGEK 541_ GETLQ 546_ PEGQV 551_ GVPGD 556_ PGLRG 561_ QPGRK 566_ GLDGI 571_ PGTPG 576_ VKGLP 581_ GPKGE 586_ LALSG 591_ EKGDQ 596_ GPPGD 601_ PGSPG 606_ SPGPA 611_ GPAGP 616_ PGYGP 621_ QGEPG 626_ LQGTQ 631_ GVPGA 636_ PGPPG 641_ EAGPR 646_ GELSV 651_ STPVP 656_ GPPGP 661_ PGPPG 666_ HPGPQ 671_ GPPGI 676_ PGSLG 681_ KCGDP 686_ GLPGP 691_ DGEPG 696_ IPGIG 701_ FPGPP 706_ GPKGD 711_ QGFPG 716_ TKGSL 721_ GCPGK 726_ MGEPG 731_ LPGKP 736_ GLPGA 741_ KGEPA 746_ VAMPG 751_ GPGTP 756_ GFPGE 761_ RGNSG 766_ EHGEI 771_ GLPGL 776_ PGLPG 781_ TPGNE 786_ GLDGP 791_ RGDPG 796_ QPGPP 801_ GEQGP 806_ PGRCI 811_ EGPRG 816_ AQGLP 821_ GLNGL 826_ KGQQG 831_ RRGKT 836_ GPKGD 841_ PGIPG 846_ LDRSG 851_ FPGET 856_ GSPGI 861_ PGHQG 866_ EMGPL 871_ GQRGY 876_ PGNPG 881_ ILGPP 886_ GEDGV 891_ IGMMG 896_ FPGAI 901_ GPPGP 906_ PGNPG 911_ TPGQR 916_ GSPGI 921_ PGVKG 926_ QRGTP 931_ GAKGE 936_ QGDKG 941_ NPGPS 946_ EISHV 951_ IGDKG 956_ EPGLK 961_ GFAGN 966_ PGEKG 971_ NRGVP 976_ GMPGL 981_ KGLKG 986_ LPGPA 991_ GPPGP 996_ RGDLG 1001_ STGNP 1006_ GEPGL 1011_ RGIPG 1016_ SMGNM 1021_ GMPGS 1026_ KGKRG 1031_ TLGFP 1036_ GRAGR 1041_ PGLPG 1046_ IHGLQ 1051_ GDKGE 1056_ PGYSE 1061_ GTRPG 1066_ PPGPT 1071_ GDPGL 1076_ PGDMG 1081_ KKGEM 1086_ GQPGP 1091_ PGHLG 1096_ PAGPE 1101_ GAPGS 1106_ PGSPG 1111_ LPGKP 1116_ GPHGD 1121_ LGFKG 1126_ IKGLL 1131_ GPPGI 1136_ RGPPG 1141_ LPGFP 1146_ GSPGP 1151_ MGIRG 1156_ DQGRD 1161_ GIPGP 1166_ AGEKG 1171_ ETGLL 1176_ RAPPG 1181_ PRGNP 1186_ GAQGA 1191_ KGDRG 1196_ APGFP 1201_ GLPGR 1206_ KGAMG 1211_ DAGPR 1216_ GPTGI 1221_ EGFPG 1226_ PPGLP 1231_ GAIIP 1236_ GQTGN 1241_ RGPPG 1246_ SRGSP 1251_ GAPGP 1256_ PGPPG 1261_ SHVIG 1266_ IKGDK 1271_ GSMGH 1276_ PGPKG 1281_ PPGTA 1286_ GDMGP 1291_ PGRLG 1296_ APGTP 1301_ GLPGP 1306_ RGDPG 1311_ FQGFP 1316_ GVKGE 1321_ KGNPG 1326_ FLGSI 1331_ GPPGP 1336_ IGPKG 1341_ PPGVR 1346_ GDPGT 1351_ LKIIS 1356_ LPGSP 1361_ GPPGT 1366_ PGEPG 1371_ MQGEP 1376_ GPPGP 1381_ PGNLG 1386_ PCGPR 1391_ GKPGK 1396_ DGKPG 1401_ TPGPA 1406_ GEKGN 1411_ KGSKG 1416_ EPGPA 1421_ GSDGL 1426_ PGLKG 1431_ KRGDS 1436_ GSPAT 1441_ WTTRG 1446_ FVFTR 1451_ HSQTT 1456_ AIPSC 1461_ PEGTV 1466_ PLYSG 1471_ FSFLF 1476_ VQGNQ 1481_ RAHGQ 1486_ DLGTL 1491_ GSCLQ 1496_ RFTTM 1501_ PFLFC 1506_ NVNDV 1511_ CNFAS 1516_ RNDYS 1521_ YWLST 1526_ PALMP 1531_ MNMAP 1536_ ITGRA 1541_ LEPYI 1546_ SRCTV 1551_ CEGPA 1556_ IAIAV 1561_ HSQTT 1566_ DIPPC 1571_ PHGWI 1576_ SLWKG 1581_ FSFIM 1586_ FTSAG 1591_ SEGTG 1596_ QALAS 1601_ PGSCL 1606_ EEFRA 1611_ SPFLE 1616_ CHGRG 1621_ TCNYY 1626_ SNSYS 1631_ FWLAS 1636_ LNPER 1641_ MFRKP 1646_ IPSTV 1651_ KAGEL 1656_ EKIIS 1661_RCQVC
1: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen
2: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms