Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
1_MEPPL 6_ PVGAQ 11_ PLATV 16_ EGMEM 21_ KGPLR 26_ EPCAL 31_ TLAQR 36_ NGQYE 41_ LIIQL 46_ HEKEQ 51_ HVQDI 56_ IPINS 61_ HFRCV 66_ QEAEE 71_ TLLID 76_ IASNS 81_ GCKIR 86_ VQGDW 91_ IRERR 96_ FEIPD 101_ EEHCL 106_ KFLSA 111_ VLAAQ 116_ KAQSQ 121_ LLVPE 126_ QKDSS 131_ SWYQK 136_ LDTKD 141_ KPSVF 146_ SGLLG 151_ FEDNF 156_ SSMNL 161_ DKKIN 166_ SQNQP 171_ TGIHR 176_ EPPPP 181_ PFSVN 186_ KMLPR 191_ EKEAS 196_ NKEQP 201_ KVTNT 206_ MRKLF 211_ VPNTQ 216_ SGQRE 221_ GLIKH 226_ ILAKR 231_ EKEYV 236_ NIQTF 241_ RFFVG 246_ TWNVN 251_ GQSPD 256_ SGLEP 261_ WLNCD 266_ PNPPD 271_ IYCIG 276_ FQELD 281_ LSTEA 286_ FFYFE 291_ SVKEQ 296_ EWSMA 301_ VERGL 306_ HSKAK 311_ YKKVQ 316_ LVRLV 321_ GMMLL 326_ IFARK 331_ DQCRY 336_ IRDIA 341_ TETVG 346_ TGIMG 351_ KMGNK 356_ GGVAV 361_ RFVFH 366_ NTTFC 371_ IVNSH 376_ LAAHV 381_ EDFER 386_ RNQDY 391_ KDICA 396_ RMSFV 401_ VPNQT 406_ LPQLN 411_ IMKHE 416_ VVIWL 421_ GDLNY 426_ RLCMP 431_ DANEV 436_ KSLIN 441_ KKDLQ 446_ RLLKF 451_ DQLNI 456_ QRTQK 461_ KAFVD 466_ FNEGE 471_ IKFIP 476_ TYKYD 481_ SKTDR 486_ WDSSG 491_ KCRVP 496_ AWCDR 501_ ILWRG 506_ TNVNQ 511_ LNYRS 516_ HMELK 521_ TSDHK 526_ PVSAL 531_ FHIGV 536_ KVVDE 541_ RRYRK 546_ VFEDS 551_ VRIMD 556_ RMEND 561_ FLPSL 566_ ELSRR 571_ EFVFE 576_ NVKFR 581_ QLQKE 586_ KFQIS 591_ NNGQV 596_ PCHFS 601_ FIPKL 606_ NDSQY 611_ CKPWL 616_ RAEPF 621_ EGYLE 626_ PNETV 631_ DISLD 636_ VYVSK 641_ DSVTI 646_ LNSGE 651_ DKIED 656_ ILVLH 661_ LDRGK 666_ DYFLT 671_ ISGNY 676_ LPSCF 681_ GTSLE 686_ ALCRM 691_ KRPIR 696_ EVPVT 701_ KLIDL 706_ EEDSF 711_ LEKEK 716_ SLLQM 721_ VPLDE 726_ GASER 731_ PLQVP 736_ KEIWL 741_ LVDHL 746_ FKYAC 751_ HQEDL 756_ FQTPG 761_ MQEEL 766_ QQIID 771_ CLDTS 776_ IPETI 781_ PGSNH 786_ SVAEA 791_ LLIFL 796_ EALPE 801_ PVICY 806_ ELYQR 811_ CLDSA 816_ YDPRI 821_ CRQVI 826_ SQLPR 831_ CHRNV 836_ FRYLM 841_ AFLRE 846_ LLKFS 851_ EYNSV 856_ NANMI 861_ ATLFT 866_ SLLLR 871_ PPPNL 876_ MARQT 881_ PSDRQ 886_ RAIQF 891_ LLGFL 896_LGSEE
1: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:25869668, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788)