1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)
1_MAGAQ 6_ PGVHA 11_ LQLEP 16_ PTVVE 21_ TLRRG 26_ SKFIK 31_ WDEET 36_ SSRNL 41_ VTLRV 46_ DPNGF 51_ FLYWT 56_ GPNME 61_ VDTLD 66_ ISSIR 71_ DTRTG 76_ RYARL 81_ PKDPK 86_ IREVL 91_ GFGGP 96_ DARLE 101_ EKLMT 106_ VVSGP 111_ DPVNT 116_ VFLNF 121_ MAVQD 126_ DTAKV 131_ WSEEL 136_ FKLAM 141_ NILAQ 146_ NASRN 151_ TFLRK 156_ AYTKL 161_ KLQVN 166_ QDGRI 171_ PVKNI 176_ LKMFS 181_ ADKKR 186_ VETAL 191_ ESCGL 196_ KFNRS 201_ ESIRP 206_ DEFSL 211_ EIFER 216_ FLNKL 221_ CLRPD 226_ IDKIL 231_ LEIGA 236_ KGKPY 241_ LTLEQ 246_ LMDFI 251_ NQKQR 256_ DPRLN 261_ EVLYP 266_ PLRPS 271_ QARLL 276_ IEKYE 281_ PNQQF 286_ LERDQ 291_ MSMEG 296_ FSRYL 301_ GGEEN 306_ GILPL 311_ EALDL 316_ STDMT 321_ QPLSA 326_ YFINS 331_ SHNTY 336_ LTAGQ 341_ LAGTS 346_ SVEMY 351_ RQALL 356_ WGCRC 361_ VELDV 366_ WKGRP 371_ PEEEP 376_ FITHG 381_ FTMTT 386_ EVPLR 391_ DVLEA 396_ IAETA 401_ FKTSP 406_ YPVIL 411_ SFENH 416_ VDSAK 421_ QQAKM 426_ AEYCR 431_ SIFGD 436_ ALLIE 441_ PLDKY 446_ PLAPG 451_ VPLPS 456_ PQDLM 461_ GRILV 466_ KNKKR 471_ HRPSA 476_ GGPDS 481_ AGRKR 486_ PLEQS 491_ NSALS 496_ ESSAA 501_ TEPSS 506_ PQLGS 511_ PSSDS 516_ CPGLS 521_ NGEEV 526_ GLEKP 531_ SLEPQ 536_ KSLGD 541_ EGLNR 546_ GPYVL 551_ GPADR 556_ EDEEE 561_ DEEEE 566_ EQTDP 571_ KKPTT 576_ DEGTA 581_ SSEVN 586_ ATEEM 591_ STLVN 596_ YIEPV 601_ KFKSF 606_ EAARK 611_ RNKCF 616_ EMSSF 621_ VETKA 626_ MEQLT 631_ KSPME 636_ FVEYN 641_ KQQLS 646_ RIYPK 651_ GTRVD 656_ SSNYM 661_ PQLFW 666_ NVGCQ 671_ LVALN 676_ FQTLD 681_ VAMQL 686_ NAGVF 691_ EYNGR 696_ SGYLL 701_ KPEFM 706_ RRPDK 711_ SFDPF 716_ TEVIV 721_ DGIVA 726_ NALRV 731_ KVISG 736_ QFLSD 741_ RKVGI 746_ YVEVD 751_ MFGLP 756_ VDTRR 761_ KYRTR 766_ TSQGN 771_ SFNPV 776_ WDEEP 781_ FDFPK 786_ VVLPT 791_ LASLR 796_ IAAFE 801_ EGGKF 806_ VGHRI 811_ LPVSA 816_ IRSGY 821_ HYVCL 826_ RNEAN 831_ QPLCL 836_ PALLI 841_ YTEAS 846_ DYIPD 851_ DHQDY 856_ AEALI 861_ NPIKH 866_ VSLMD 871_ QRARQ 876_ LAALI 881_ GESEA 886_ QAGQE 891_ TCQDT 896_ QSQQL 901_ GSQPS 906_ SNPTP 911_ SPLDA 916_ SPRRP 921_ PGPTT 926_ SPAST 931_ SLSSP 936_ GQRDD 941_ LIASI 946_ LSEVA 951_ PTPLD 956_ ELRGH 961_ KALVK 966_ LRSRQ 971_ ERDLR 976_ ELRKK 981_ HQRKA 986_ VTLTR 991_ RLLDG 996_ LAQAQ 1001_ AEGRC 1006_ RLRPG 1011_ ALGGA 1016_ ADVED 1021_ TKEGE 1026_ DEAKR 1031_ YQEFQ 1036_ NRQVQ 1041_ SLLEL 1046_ REAQV 1051_ DAEAQ 1056_ RRLEH 1061_ LRQAL 1066_ QRLRE 1071_ VVLDA 1076_ NTTQF 1081_ KRLKE 1086_ MNERE 1091_ KKELQ 1096_ KILDR 1101_ KRHNS 1106_ ISEAK 1111_ MRDKH 1116_ KKEAE 1121_ LTEIN 1126_ RRHIT 1131_ ESVNS 1136_ IRRLE 1141_ EAQKQ 1146_ RHDRL 1151_ VAGQQ 1156_ QVLQQ 1161_ LAEEE 1166_ PKLLA 1171_ QLAQE 1176_ CQEQR 1181_ ARLPQ 1186_ EIRRS 1191_ LLGEM 1196_ PEGLG 1201_ DGPLV 1206_ ACASN 1211_ GHAPG 1216_ SSGHL 1221_ SGADS 1226_ESQEE
1: Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity)