Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)
1_MGRKK 6_ IQITR 11_ IMDER 16_ NRQVT 21_ FTKRK 26_ FGLMK 31_ KAYEL 36_ SVLCD 41_ CEIAL 46_ IIFNS 51_ SNKLF 56_ QYAST 61_ DMDKV 66_ LLKYT 71_ EYNEP 76_ HESRT 81_ NSDIV 86_ EALNK 91_ KEHRG 96_ CDSPD 101_ PDTSY 106_ VLTPH 111_ TEEKY 116_ KKINE 121_ EFDNM 126_ MRNHK 131_ IAPGL 136_ PPQNF 141_ SMSVT 146_ VPVTS 151_ PNALS 156_ YTNPG 161_ SSLVS 166_ PSLAA 171_ SSTLT 176_ DSSML 181_ SPPQT 186_ TLHRN 191_ VSPGA 196_ PQRPP 201_ STGNA 206_ GGMLS 211_ TTDLT 216_ VPNGA 221_ GSSPV 226_ GNGFV 231_ NSRAS 236_ PNLIG 241_ ATGAN 246_ SLGKV 251_ MPTKS 256_ PPPPG 261_ GGNLG 266_ MNSRK 271_ PDLRV 276_ VIPPS 281_ SKGMM 286_ PPLSE 291_ EEELE 296_ LNTQR 301_ ISSSQ 306_ ATQPL 311_ ATPVV 316_ SVTTP 321_ SLPPQ 326_ GLVYS 331_ AMPTA 336_ YNTDY 341_ SLTSA 346_ DLSAL 351_ QGFNS 356_ PGMLS 361_ LGQVS 366_ AWQQH 371_ HLGQA 376_ ALSSL 381_ VAGGQ 386_ LSQGS 391_ NLSIN 396_ TNQNI 401_ SIKSE 406_ PISPP 411_ RDRMT 416_ PSGFQ 421_ QQQQQ 426_ QQQQQ 431_ PPPPP 436_ QPQPQ 441_ PPQPQ 446_ PRQEM 451_ GRSPV 456_ DSLSS 461_ SSSSY 466_ DGSDR 471_ EDPRG 476_ DFHSP 481_ IVLGR 486_ PPNTE 491_ DRESP 496_ SVKRM 501_RMDAW
1: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter