N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]
1_MRTAD 6_ REARP 11_ GLPSL 16_ LLLLL 21_ AGAGL 26_ SAASP 31_ PAAPR 36_ FNVSL 41_ DSVPE 46_ LRWLP 51_ VLRHY 56_ DLDLV 61_ RAAMA 66_ QVIGD 71_ RVPKW 76_ VHVLI 81_ GKVVL 86_ ELERF 91_ LPQPF 96_ TGEIR 101_ GMCDF 106_ MNLSL 111_ ADCLL 116_ VNLAY 121_ ESSVF 126_ CTSIV 131_ AQDSR 136_ GHIYH 141_ GRNLD 146_ YPFGN 151_ VLRKL 156_ TVDVQ 161_ FLKNG 166_ QIAFT 171_ GTTFI 176_ GYVGL 181_ WTGQS 186_ PHKFT 191_ VSGDE 196_ RDKGW 201_ WWENA 206_ IAALF 211_ RRHIP 216_ VSWLI 221_ RATLS 226_ ESENF 231_ EAAVG 236_ KLAKT 241_ PLIAD 246_ VYYIV 251_ GGTSP 256_ REGVV 261_ ITRNR 266_ DGPAD 271_ IWPLD 276_ PLNGA 281_ WFRVE 286_ TNYDH 291_ WKPAP 296_ KEDDR 301_ RTSAI 306_ KALNA 311_ TGQAN 316_ LSLEA 321_ LFQIL 326_ SVVPV 331_ YNNFT 336_ IYTTV 341_ MSAGS 346_ PDKYM 351_TRIRN
1: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:22825852, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246)