2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)
1_MFHLR 6_ TCAAK 11_ LRPLT 16_ ASQTV 21_ KTFSQ 26_ NRPAA 31_ ARTFQ 36_ QIRCY 41_ SAPVA 46_ AEPFL 51_ SGTSS 56_ NYVEE 61_ MYCAW 66_ LENPK 71_ SVHKS 76_ WDIFF 81_ RNTNA 86_ GAPPG 91_ TAYQS 96_ PLPLS 101_ RGSLA 106_ AVAHA 111_ QSLVE 116_ AQPNV 121_ DKLVE 126_ DHLAV 131_ QSLIR 136_ AYQIR 141_ GHHVA 146_ QLDPL 151_ GILDA 156_ DLDSS 161_ VPADI 166_ ISSTD 171_ KLGFY 176_ GLDES 181_ DLDKV 186_ FHLPT 191_ TTFIG 196_ GQESA 201_ LPLRE 206_ IIRRL 211_ EMAYC 216_ QHIGV 221_ EFMFI 226_ NDLEQ 231_ CQWIR 236_ QKFET 241_ PGIMQ 246_ FTNEE 251_ KRTLL 256_ ARLVR 261_ STRFE 266_ EFLQR 271_ KWSSE 276_ KRFGL 281_ EGCEV 286_ LIPAL 291_ KTIID 296_ KSSEN 301_ GVDYV 306_ IMGMP 311_ HRGRL 316_ NVLAN 321_ VIRKE 326_ LEQIF 331_ CQFDS 336_ KLEAA 341_ DEGSG 346_ DVKYH 351_ LGMYH 356_ RRINR 361_ VTDRN 366_ ITLSL 371_ VANPS 376_ HLEAA 381_ DPVVM 386_ GKTKA 391_ EQFYC 396_ GDTEG 401_ KKVMS 406_ ILLHG 411_ DAAFA 416_ GQGIV 421_ YETFH 426_ LSDLP 431_ SYTTH 436_ GTVHV 441_ VVNNQ 446_ IGFTT 451_ DPRMA 456_ RSSPY 461_ PTDVA 466_ RVVNA 471_ PIFHV 476_ NSDDP 481_ EAVMY 486_ VCKVA 491_ AEWRS 496_ TFHKD 501_ VVVDL 506_ VCYRR 511_ NGHNE 516_ MDEPM 521_ FTQPL 526_ MYKQI 531_ RKQKP 536_ VLQKY 541_ AELLV 546_ SQGVV 551_ NQPEY 556_ EEEIS 561_ KYDKI 566_ CEEAF 571_ ARSKD 576_ EKILH 581_ IKHWL 586_ DSPWP 591_ GFFTL 596_ DGQPR 601_ SMSCP 606_ STGLT 611_ EDILT 616_ HIGNV 621_ ASSVP 626_ VENFT 631_ IHGGL 636_ SRILK 641_ TRGEM 646_ VKNRT 651_ VDWAL 656_ AEYMA 661_ FGSLL 666_ KEGIH 671_ IRLSG 676_ QDVER 681_ GTFSH 686_ RHHVL 691_ HDQNV 696_ DKRTC 701_ IPMNH 706_ LWPNQ 711_ APYTV 716_ CNSSL 721_ SEYGV 726_ LGFEL 731_ GFAMA 736_ SPNAL 741_ VLWEA 746_ QFGDF 751_ HNTAQ 756_ CIIDQ 761_ FICPG 766_ QAKWV 771_ RQNGI 776_ VLLLP 781_ HGMEG 786_ MGPEH 791_ SSARP 796_ ERFLQ 801_ MCNDD 806_ PDVLP 811_ DLKEA 816_ NFDIN 821_ QLYDC 826_ NWVVV 831_ NCSTP 836_ GNFFH 841_ VLRRQ 846_ ILLPF 851_ RKPLI 856_ IFTPK 861_ SLLRH 866_ PEARS 871_ SFDEM 876_ LPGTH 881_ FQRVI 886_ PEDGP 891_ AAQNP 896_ ENVKR 901_ LLFCT 906_ GKVYY 911_ DLTRE 916_ RKARD 921_ MVGQV 926_ AITRI 931_ EQLSP 936_ FPFDL 941_ LLKEV 946_ QKYPN 951_ AELAW 956_ CQEEH 961_ KNQGY 966_ YDYVK 971_ PRLRT 976_ TISRA 981_ KPVWY 986_ AGRDP 991_ AAAPA 996_ TGNKK 1001_ THLTE 1006_ LQRLL 1011_ DTAFD 1016_LDVFK
1: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050, PubMed:35272141). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711)