Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)
1_MAEEG 6_ AVAVC 11_ VRVRP 16_ LNSRE 21_ ESLGE 26_ TAQVY 31_ WKTDN 36_ NVIYQ 41_ VDGSK 46_ SFNFD 51_ RVFHG 56_ NETTK 61_ NVYEE 66_ IAAPI 71_ IDSAI 76_ QGYNG 81_ TIFAY 86_ GQTAS 91_ GKTYT 96_ MMGSE 101_ DHLGV 106_ IPRAI 111_ HDIFQ 116_ KIKKF 121_ PDREF 126_ LLRVS 131_ YMEIY 136_ NETIT 141_ DLLCG 146_ TQKMK 151_ PLIIR 156_ EDVNR 161_ NVYVA 166_ DLTEE 171_ VVYTS 176_ EMALK 181_ WITKG 186_ EKSRH 191_ YGETK 196_ MNQRS 201_ SRSHT 206_ IFRMI 211_ LESRE 216_ KGEPS 221_ NCEGS 226_ VKVSH 231_ LNLVD 236_ LAGSE 241_ RAAQT 246_ GAAGV 251_ RLKEG 256_ CNINR 261_ SLFIL 266_ GQVIK 271_ KLSDG 276_ QVGGF 281_ INYRD 286_ SKLTR 291_ ILQNS 296_ LGGNA 301_ KTRII 306_ CTITP 311_ VSFDE 316_ TLTAL 321_ QFAST 326_ AKYMK 331_ NTPYV 336_ NEVST 341_ DEALL 346_ KRYRK 351_ EIMDL 356_ KKQLE 361_ EVSLE 366_ TRAQA 371_ MEKDQ 376_ LAQLL 381_ EEKDL 386_ LQKVQ 391_ NEKIE 396_ NLTRM 401_ LVTSS 406_ SLTLQ 411_ QELKA 416_ KRKRR 421_ VTWCL 426_ GKINK 431_ MKNSN 436_ YADQF 441_ NIPTN 446_ ITTKT 451_ HKLSI 456_ NLLRE 461_ IDESV 466_ CSESD 471_ VFSNT 476_ LDTLS 481_ EIEWN 486_ PATKL 491_ LNQEN 496_ IESEL 501_ NSLRA 506_ DYDNL 511_ VLDYE 516_ QLRTE 521_ KEEME 526_ LKLKE 531_ KNDLD 536_ EFEAL 541_ ERKTK 546_ KDQEM 551_ QLIHE 556_ ISNLK 561_ NLVKH 566_ AEVYN 571_ QDLEN 576_ ELSSK 581_ VELLR 586_ EKEDQ 591_ IKKLQ 596_ EYIDS 601_ QKLEN 606_ IKMDL 611_ SYSLE 616_ SIEDP 621_ KQMKQ 626_ TLFDA 631_ ETVAL 636_ DAKRE 641_ SAFLR 646_ SENLE 651_ LKEKM 656_ KELAT 661_ TYKQM 666_ ENDIQ 671_ LYQSQ 676_ LEAKK 681_ KMQVD 686_ LEKEL 691_ QSAFN 696_ EITKL 701_ TSLID 706_ GKVPK 711_ DLLCN 716_ LELEG 721_ KITDL 726_ QKELN 731_ KEVEE 736_ NEALR 741_ EEVIL 746_ LSELK 751_ SLPSE 756_ VERLR 761_ KEIQD 766_ KSEEL 771_ HIITS 776_ EKDKL 781_ FSEVV 786_ HKESR 791_ VQGLL 796_ EEIGK 801_ TKDDL 806_ ATTQS 811_ NYKST 816_ DQEFQ 821_ NFKTL 826_ HMDFE 831_ QKYKM 836_ VLEEN 841_ ERMNQ 846_ EIVNL 851_ SKEAQ 856_ KFDSS 861_ LGALK 866_ TELSY 871_ KTQEL 876_ QEKTR 881_ EVQER 886_ LNEME 891_ QLKEQ 896_ LENRD 901_ STLQT 906_ VEREK 911_ TLITE 916_ KLQQT 921_ LEEVK 926_ TLTQE 931_ KDDLK 936_ QLQES 941_ LQIER 946_ DQLKS 951_ DIHDT 956_ VNMNI 961_ DTQEQ 966_ LRNAL 971_ ESLKQ 976_ HQETI 981_ NTLKS 986_ KISEE 991_ VSRNL 996_ HMEEN 1001_ TGETK 1006_ DEFQQ 1011_ KMVGI 1016_ DKKQD 1021_ LEAKN 1026_ TQTLT 1031_ ADVKD 1036_ NEIIE 1041_ QQRKI 1046_ FSLIQ 1051_ EKNEL 1056_ QQMLE 1061_ SVIAE 1066_ KEQLK 1071_ TDLKE 1076_ NIEMT 1081_ IENQE 1086_ ELRLL 1091_ GDELK 1096_ KQQEI 1101_ VAQEK 1106_ NHAIK 1111_ KEGEL 1116_ SRTCD 1121_ RLAEV 1126_ EEKLK 1131_ EKSQQ 1136_ LQEKQ 1141_ QQLLN 1146_ VQEEM 1151_ SEMQK 1156_ KINEI 1161_ ENLKN 1166_ ELKNK 1171_ ELTLE 1176_ HMETE 1181_ RLELA 1186_ QKLNE 1191_ NYEEV 1196_ KSITK 1201_ ERKVL 1206_ KELQK 1211_ SFETE 1216_ RDHLR 1221_ GYIRE 1226_ IEATG 1231_ LQTKE 1236_ ELKIA 1241_ HIHLK 1246_ EHQET 1251_ IDELR 1256_ RSVSE 1261_ KTAQI 1266_ INTQD 1271_ LEKSH 1276_ TKLQE 1281_ EIPVL 1286_ HEEQE 1291_ LLPNV 1296_ KEVSE 1301_ TQETM 1306_ NELEL 1311_ LTEQS 1316_ TTKDS 1321_ TTLAR 1326_ IEMER 1331_ LRLNE 1336_ KFQES 1341_ QEEIK 1346_ SLTKE 1351_ RDNLK 1356_ TIKEA 1361_ LEVKH 1366_ DQLKE 1371_ HIRET 1376_ LAKIQ 1381_ ESQSK 1386_ QEQSL 1391_ NMKEK 1396_ DNETT 1401_ KIVSE 1406_ MEQFK 1411_ PKDSA 1416_ LLRIE 1421_ IEMLG 1426_ LSKRL 1431_ QESHD 1436_ EMKSV 1441_ AKEKD 1446_ DLQRL 1451_ QEVLQ 1456_ SESDQ 1461_ LKENI 1466_ KEIVA 1471_ KHLET 1476_ EEELK 1481_ VAHCC 1486_ LKEQE 1491_ ETINE 1496_ LRVNL 1501_ SEKET 1506_ EISTI 1511_ QKQLE 1516_ AINDK 1521_ LQNKI 1526_ QEIYE 1531_ KEEQF 1536_ NIKQI 1541_ SEVQE 1546_ KVNEL 1551_ KQFKE 1556_ HRKAK 1561_ DSALQ 1566_ SIESK 1571_ MLELT 1576_ NRLQE 1581_ SQEEI 1586_ QIMIK 1591_ EKEEM 1596_ KRVQE 1601_ ALQIE 1606_ RDQLK 1611_ ENTKE 1616_ IVAKM 1621_ KESQE 1626_ KEYQF 1631_ LKMTA 1636_ VNETQ 1641_ EKMCE 1646_ IEHLK 1651_ EQFET 1656_ QKLNL 1661_ ENIET 1666_ ENIRL 1671_ TQILH 1676_ ENLEE 1681_ MRSVT 1686_ KERDD 1691_ LRSVE 1696_ ETLKV 1701_ ERDQL 1706_ KENLR 1711_ ETITR 1716_ DLEKQ 1721_ EELKI 1726_ VHMHL 1731_ KEHQE 1736_ TIDKL 1741_ RGIVS 1746_ EKTNE 1751_ ISNMQ 1756_ KDLEH 1761_ SNDAL 1766_ KAQDL 1771_ KIQEE 1776_ LRIAH 1781_ MHLKE 1786_ QQETI 1791_ DKLRG 1796_ IVSEK 1801_ TDKLS 1806_ NMQKD 1811_ LENSN 1816_ AKLQE 1821_ KIQEL 1826_ KANEH 1831_ QLITL 1836_ KKDVN 1841_ ETQKK 1846_ VSEME 1851_ QLKKQ 1856_ IKDQS 1861_ LTLSK 1866_ LEIEN 1871_ LNLAQ 1876_ KLHEN 1881_ LEEMK 1886_ SVMKE 1891_ RDNLR 1896_ RVEET 1901_ LKLER 1906_ DQLKE 1911_ SLQET 1916_ KARDL 1921_ EIQQE 1926_ LKTAR 1931_ MLSKE 1936_ HKETV 1941_ DKLRE 1946_ KISEK 1951_ TIQIS 1956_ DIQKD 1961_ LDKSK 1966_ DELQK 1971_ KIQEL 1976_ QKKEL 1981_ QLLRV 1986_ KEDVN 1991_ MSHKK 1996_ INEME 2001_ QLKKQ 2006_ FEAQN 2011_ LSMQS 2016_ VRMDN 2021_ FQLTK 2026_ KLHES 2031_ LEEIR 2036_ IVAKE 2041_ RDELR 2046_ RIKES 2051_ LKMER 2056_ DQFIA 2061_ TLREM 2066_ IARDR 2071_ QNHQV 2076_ KPEKR 2081_ LLSDG 2086_ QQHLT 2091_ ESLRE 2096_ KCSRI 2101_ KELLK 2106_ RYSEM 2111_ DDHYE 2116_ CLNRL 2121_ SLDLE 2126_ KEIEF 2131_ QKELS 2136_ MRVKA 2141_ NLSLP 2146_ YLQTK 2151_ HIEKL 2156_ FTANQ 2161_ RCSME 2166_ FHRIM 2171_ KKLKY 2176_ VLSYV 2181_ TKIKE 2186_ EQHES 2191_ INKFE 2196_ MDFID 2201_ EVEKQ 2206_ KELLI 2211_ KIQHL 2216_ QQDCD 2221_ VPSRE 2226_ LRDLK 2231_ LNQNM 2236_ DLHIE 2241_ EILKD 2246_ FSESE 2251_ FPSIK 2256_ TEFQQ 2261_ VLSNR 2266_ KEMTQ 2271_ FLEEW 2276_ LNTRF 2281_ DIEKL 2286_ KNGIQ 2291_ KENDR 2296_ ICQVN 2301_ NFFNN 2306_ RIIAI 2311_ MNEST 2316_ EFEER 2321_ SATIS 2326_ KEWEQ 2331_ DLKSL 2336_ KEKNE 2341_ KLFKN 2346_ YQTLK 2351_ TSLAS 2356_ GAQVN 2361_ PTTQD 2366_ NKNPH 2371_ VTSRA 2376_ TQLTT 2381_ EKIRE 2386_ LENSL 2391_ HEAKE 2396_ SAMHK 2401_ ESKII 2406_ KMQKE 2411_ LEVTN 2416_ DIIAK 2421_ LQAKV 2426_ HESNK 2431_ CLEKT 2436_ KETIQ 2441_ VLQDK 2446_ VALGA 2451_ KPYKE 2456_ EIEDL 2461_ KMKLV 2466_ KIDLE 2471_ KMKNA 2476_ KEFEK 2481_ EISAT 2486_ KATVE 2491_ YQKEV 2496_ IRLLR 2501_ ENLRR 2506_ SQQAQ 2511_ DTSVI 2516_ SEHTD 2521_ PQPSN 2526_ KPLTC 2531_ GGGSG 2536_ IVQNT 2541_ KALIL 2546_ KSEHI 2551_ RLEKE 2556_ ISKLK 2561_ QQNEQ 2566_ LIKQK 2571_ NELLS 2576_ NNQHL 2581_ SNEVK 2586_ TWKER 2591_ TLKRE 2596_ AHKQV 2601_ TCENS 2606_ PKSPK 2611_ VTGTA 2616_ SKKKQ 2621_ ITPSQ 2626_ CKERN 2631_ LQDPV 2636_ PKESP 2641_ KSCFF 2646_ DSRSK 2651_ SLPSP 2656_ HPVRY 2661_ FDNSS 2666_ LGLCP 2671_ EVQNA 2676_ GAESV 2681_ DSQPG 2686_ PWHAS 2691_ SGKDV 2696_PECKT
1: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity)