Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
1_MSERK 6_ EGRGK 11_ GKGKK 16_ KERGS 21_ GKKPE 26_ SAAGS 31_ QSPAL 36_ PPRLK 41_ EMKSQ 46_ ESAAG 51_ SKLVL 56_ RCETS 61_ SEYSS 66_ LRFKW 71_ FKNGN 76_ ELNRK 81_ NKPQN 86_ IKIQK 91_ KPGKS 96_ ELRIN 101_ KASLA 106_ DSGEY 111_ MCKVI 116_ SKLGN 121_ DSASA 126_ NITIV 131_ ESNEI 136_ ITGMP 141_ ASTEG 146_ AYVSS 151_ ESPIR 156_ ISVST 161_ EGANT 166_ SSSTS 171_ TSTTG 176_ TSHLV 181_ KCAEK 186_ EKTFC 191_ VNGGE 196_ CFMVK 201_ DLSNP 206_ SRYLC 211_ KCQPG 216_ FTGAR 221_ CTENV 226_ PMKVQ 231_ NQEKA 236_ EELYQ 241_ KRVLT 246_ ITGIC 251_ IALLV 256_ VGIMC 261_ VVAYC 266_ KTKKQ 271_ RKKLH 276_ DRLRQ 281_ SLRSE 286_ RNNMM 291_ NIANG 296_ PHHPN 301_ PPPEN 306_ VQLVN 311_ QYVSK 316_ NVISS 321_ EHIVE 326_ REAET 331_ SFSTS 336_ HYTST 341_ AHHST 346_ TVTQT 351_ PSHSW 356_ SNGHT 361_ ESILS 366_ ESHSV 371_ IVMSS 376_ VENSR 381_ HSSPT 386_ GGPRG 391_ RLNGT 396_ GGPRE 401_ CNSFL 406_ RHARE 411_ TPDSY 416_ RDSPH 421_ SERYV 426_ SAMTT 431_ PARMS 436_ PVDFH 441_ TPSSP 446_ KSPPS 451_ EMSPP 456_ VSSMT 461_ VSMPS 466_ MAVSP 471_ FMEEE 476_ RPLLL 481_ VTPPR 486_ LREKK 491_ FDHHP 496_ QQFSS 501_ FHHNP 506_ AHDSN 511_ SLPAS 516_ PLRIV 521_ EDEEY 526_ ETTQE 531_ YEPAQ 536_ EPVKK 541_ LANSR 546_ RAKRT 551_ KPNGH 556_ IANRL 561_ EVDSN 566_ TSSQS 571_ SNSES 576_ ETEDE 581_ RVGED 586_ TPFLG 591_ IQNPL 596_ AASLE 601_ ATPAF 606_ RLADS 611_ RTNPA 616_ GRFST 621_ QEEIQ 626_ ARLSS 631_VIANQ
1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)