DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
1_MKAFS 6_ PVRSV 11_ RKNSL 16_ SDHSL 21_ GISRS 26_ KTPVD 31_ DPMSL 36_ LYNMN 41_ DCYSK 46_ LKELV 51_ PSIPQ 56_ NKKVS 61_ KMEIL 66_ QHVID 71_ YILDL 76_ QIALD 81_ SHPTI 86_ VSLHH 91_ QRPGQ 96_ NQASR 101_ TPLTT 106_ LNTDI 111_ SILSL 116_ QASEF 121_ PSELM 126_SNDSK
1: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism