Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
1_MEAAR 6_ PSGSW 11_ NGALC 16_ RLLLL 21_ TLAIL 26_ IFASD 31_ ACKNV 36_ TLHVP 41_ SKLDA 46_ EKLVG 51_ RVNLK 56_ ECFTA 61_ ANLIH 66_ SSDPD 71_ FQILE 76_ DGSVY 81_ TTNTI 86_ LLSSE 91_ KRSFT 96_ ILLSN 101_ TENQE 106_ KKKIF 111_ VFLEH 116_ QTKVL 121_ KKRHT 126_ KEKVL 131_ RRAKR 136_ RWAPI 141_ PCSML 146_ ENSLG 151_ PFPLF 156_ LQQVQ 161_ SDTAQ 166_ NYTIY 171_ YSIRG 176_ PGVDQ 181_ EPRNL 186_ FYVER 191_ DTGNL 196_ YCTRP 201_ VDREQ 206_ YESFE 211_ IIAFA 216_ TTPDG 221_ YTPEL 226_ PLPLI 231_ IKIED 236_ ENDNY 241_ PIFTE 246_ ETYTF 251_ TIFEN 256_ CRVGT 261_ TVGQV 266_ CATDK 271_ DEPDT 276_ MHTRL 281_ KYSII 286_ GQVPP 291_ SPTLF 296_ SMHPT 301_ TGVIT 306_ TTSSQ 311_ LDREL 316_ IDKYQ 321_ LKIKV 326_ QDMDG 331_ QYFGL 336_ QTTST 341_ CIINI 346_ DDVND 351_ HLPTF 356_ TRTSY 361_ VTSVE 366_ ENTVD 371_ VEILR 376_ VTVED 381_ KDLVN 386_ TANWR 391_ ANYTI 396_ LKGNE 401_ NGNFK 406_ IVTDA 411_ KTNEG 416_ VLCVV 421_ KPLNY 426_ EEKQQ 431_ MILQI 436_ GVVNE 441_ APFSR 446_ EASPR 451_ SAMST 456_ ATVTV 461_ NVEDQ 466_ DEGPE 471_ CNPPI 476_ QTVRM 481_ KENAE 486_ VGTTS 491_ NGYKA 496_ YDPET 501_ RSSSG 506_ IRYKK 511_ LTDPT 516_ GWVTI 521_ DENTG 526_ SIKVF 531_ RSLDR 536_ EAETI 541_ KNGIY 546_ NITVL 551_ ASDQG 556_ GRTCT 561_ GTLGI 566_ ILQDV 571_ NDNSP 576_ FIPKK 581_ TVIIC 586_ KPTMS 591_ SAEIV 596_ AVDPD 601_ EPIHG 606_ PPFDF 611_ SLESS 616_ TSEVQ 621_ RMWRL 626_ KAIND 631_ TAARL 636_ SYQND 641_ PPFGS 646_ YVVPI 651_ TVRDR 656_ LGMSS 661_ VTSLD 666_ VTLCD 671_ CITEN 676_ DCTHR 681_ VDPRI 686_ GGGGV 691_ QLGKW 696_ AILAI 701_ LLGIA 706_ LLFCI 711_ LFTLV 716_ CGASG 721_ TSKQP 726_ KVIPD 731_ DLAQQ 736_ NLIVS 741_ NTEAP 746_ GDDKV 751_ YSANG 756_ FTTQT 761_ VGASA 766_ QGVCG 771_ TVGSG 776_ IKNGG 781_ QETIE 786_ MVKGG 791_ HQTSE 796_ SCRGA 801_ GHHHT 806_ LDSCR 811_ GGHTE 816_ VDNCR 821_ YTYSE 826_ WHSFT 831_ QPRLG 836_ EKVYL 841_ CNQDE 846_ NHKHA 851_ QDYVL 856_ TYNYE 861_ GRGSV 866_ AGSVG 871_ CCSER 876_ QEEDG 881_ LEFLD 886_ NLEPK 891_ FRTLA 896_EACMK
1: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity)