DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
1_MKALS 6_ PVRGC 11_ YEAVC 16_ CLSER 21_ SLAIA 26_ RGRGK 31_ GPAAE 36_ EPLSL 41_ LDDMN 46_ HCYSR 51_ LRELV 56_ PGVPR 61_ GTQLS 66_ QVEIL 71_ QRVID 76_ YILDL 81_ QVVLA 86_ EPAPG 91_ PPDGP 96_ HLPIQ 101_ TAELT 106_ PELVI 111_SNDKR
1: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer