Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
1_MDLEK 6_ NYPTP 11_ RTSRT 16_ GHGGV 21_ NQLGG 26_ VFVNG 31_ RPLPD 36_ VVRQR 41_ IVELA 46_ HQGVR 51_ PCDIS 56_ RQLRV 61_ SHGCV 66_ SKILG 71_ RYYET 76_ GSIKP 81_ GVIGG 86_ SKPKV 91_ ATPKV 96_ VEKIA 101_ EYKRQ 106_ NPTMF 111_ AWEIR 116_ DRLLA 121_ ERVCD 126_ NDTVP 131_ SVSSI 136_ NRIIR 141_ TKVQQ 146_ PPNQP 151_ VPASS 156_ HSIVS 161_ TGSVT 166_ QVSSV 171_ STDSA 176_ GSSYS 181_ ISGIL 186_ GITSP 191_ SADTN 196_ KRKRD 201_ EGIQE 206_ SPVPN 211_ GHSLP 216_ GRDFL 221_ RKQMR 226_ GDLFT 231_ QQQLE 236_ VLDRV 241_ FERQH 246_ YSDIF 251_ TTTEP 256_ IKPEQ 261_ TTEYS 266_ AMASL 271_ AGGLD 276_ DMKAN 281_ LASPT 286_ PADIG 291_ SSVPG 296_ PQSYP 301_ IVTGR 306_ DLAST 311_ TLPGY 316_ PPHVP 321_ PAGQG 326_ SYSAP 331_ TLTGM 336_ VPGSE 341_ FSGSP 346_ YSHPQ 351_ YSSYN 356_ DSWRF 361_ PNPGL 366_ LGSPY 371_ YYSAA 376_ ARGAA 381_ PPAAA 386_TAYDR
1: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238)
2: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172)