Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
1_MCDRN 6_ GGRRL 11_ RQWLI 16_ EQIDS 21_ SMYPG 26_ LIWEN 31_ EEKSM 36_ FRIPW 41_ KHAGK 46_ QDYNQ 51_ EVDAS 56_ IFKAW 61_ AVFKG 66_ KFKEG 71_ DKAEP 76_ ATWKT 81_ RLRCA 86_ LNKSP 91_ DFEEV 96_ TDRSQ 101_ LDISE 106_ PYKVY 111_ RIVPE 116_ EEQKC 121_ KLGVA 126_ TAGCV 131_ NEVTE 136_ MECGR 141_ SEIDE 146_ LIKEP 151_ SVDDY 156_ MGMIK 161_ RSPSP 166_ PEACR 171_ SQLLP 176_ DWWAQ 181_ QPSTG 186_ VPLVT 191_ GYTTY 196_ DAHHS 201_ AFSQM 206_ VISFY 211_ YGGKL 216_ VGQAT 221_ TTCPE 226_ GCRLS 231_ LSQPG 236_ LPGTK 241_ LYGPE 246_ GLELV 251_ RFPPA 256_ DAIPS 261_ ERQRQ 266_ VTRKL 271_ FGHLE 276_ RGVLL 281_ HSSRQ 286_ GVFVK 291_ RLCQG 296_ RVFCS 301_ GNAVV 306_ CKGRP 311_ NKLER 316_ DEVVQ 321_ VFDTS 326_ QFFRE 331_ LQQFY 336_ NSQGR 341_ LPDGR 346_ VVLCF 351_ GEEFP 356_ DMAPL 361_ RSKLI 366_ LVQIE 371_ QLYVR 376_ QLAEE 381_ AGKSC 386_ GAGSV 391_ MQAPE 396_ EPPPD 401_ QVFRM 406_ FPDIC 411_ ASHQR 416_ SFFRE 421_NQQIT
1: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity)