Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2)
1_MMLSP 6_ DQAAD 11_ SDHPS 16_ SAHSD 21_ PESLG 26_ GTDTK 31_ VLGSV 36_ SDLEP 41_ VEEAE 46_ GDGKG 51_ GSRAA 56_ LYPHP 61_ QQLSR 66_ EEKRR 71_ RRRAT 76_ AKYRS 81_ AHATR 86_ ERIRV 91_ EAFNL 96_ AFAEL 101_ RKLLP 106_ TLPPD 111_ KKLSK 116_ IEILR 121_ LAICY 126_ISYLN
1: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN, PCSK1, MC4R (By similarity). Is also a transcriptional activator of KISS1 (PubMed:35066646). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons