Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)
1_MLRTL 6_ LRRRL 11_ FSYPT 16_ KYYFM 21_ VLVLS 26_ LITFS 31_ VLRIH 36_ QKPEF 41_ VSVRH 46_ LELAG 51_ ENPSS 56_ DINCT 61_ KVLQG 66_ DVNEI 71_ QKVKL 76_ EILTV 81_ KFKKR 86_ PRWTP 91_ DDYIN 96_ MTSDC 101_ SSFIK 106_ RRKYI 111_ VEPLS 116_ KEEAE 121_ FPIAY 126_ SIVVH 131_ HKIEM 136_ LDRLL 141_ RAIYM 146_ PQNFY 151_ CIHVD 156_ TKSED 161_ SYLAA 166_ VMGIA 171_ SCFSN 176_ VFVAS 181_ RLESV 186_ VYASW 191_ SRVQA 196_ DLNCM 201_ KDLYA 206_ MSANW 211_ KYLIN 216_ LCGMD 221_ FPIKT 226_ NLEIV 231_ RKLKL 236_ LMGEN 241_ NLETE 246_ RMPSH 251_ KEERW 256_ KKRYE 261_ VVNGK 266_ LTNTG 271_ TVKML 276_ PPLET 281_ PLFSG 286_ SAYFV 291_ VSREY 296_ VGYVL 301_ QNEKI 306_ QKLME 311_ WAQDT 316_ YSPDE 321_ YLWAT 326_ IQRIP 331_ EVPGS 336_ LPASH 341_ KYDLS 346_ DMQAV 351_ ARFVK 356_ WQYFE 361_ GDVSK 366_ GAPYP 371_ PCDGV 376_ HVRSV 381_ CIFGA 386_ GDLNW 391_ MLRKH 396_ HLFAN 401_ KFDVD 406_ VDLFA 411_ IQCLD 416_ EHLRH 421_KALET
1: Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity)