Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
1_MTAEE 6_ MKATE 11_ SGAQS 16_ APLPM 21_ EGVDI 26_ SPKQD 31_ EGVLK 36_ VIKRE 41_ GTGTE 46_ MPMIG 51_ DRVFV 56_ HYTGW 61_ LLDGT 66_ KFDSS 71_ LDRKD 76_ KFSFD 81_ LGKGE 86_ VIKAW 91_ DIAIA 96_ TMKVG 101_ EVCHI 106_ TCKPE 111_ YAYGS 116_ AGSPP 121_ KIPPN 126_ ATLVF 131_ EVELF 136_ EFKGE 141_ DLTEE 146_ EDGGI 151_ IRRIQ 156_ TRGEG 161_ YAKPN 166_ EGAIV 171_ EVALE 176_ GYYKD 181_ KLFDQ 186_ RELRF 191_ EIGEG 196_ ENLDL 201_ PYGLE 206_ RAIQR 211_ MEKGE 216_ HSIVY 221_ LKPSY 226_ AFGSV 231_ GKEKF 236_ QIPPN 241_ AELKY 246_ ELHLK 251_ SFEKA 256_ KESWE 261_ MNSEE 266_ KLEQS 271_ TIVKE 276_ RGTVY 281_ FKEGK 286_ YKQAL 291_ LQYKK 296_ IVSWL 301_ EYESS 306_ FSNEE 311_ AQKAQ 316_ ALRLA 321_ SHLNL 326_ AMCHL 331_ KLQAF 336_ SAAIE 341_ SCNKA 346_ LELDS 351_ NNEKG 356_ LFRRG 361_ EAHLA 366_ VNDFE 371_ LARAD 376_ FQKVL 381_ QLYPN 386_ NKAAK 391_ TQLAV 396_ CQQRI 401_ RRQLA 406_ REKKL 411_ YANMF 416_ ERLAE 421_ EENKA 426_ KAEAS 431_ SGDHP 436_ TDTEM 441_ KEEQK 446_ SNTAG 451_SQSQV
1: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria