Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)
1_MTACA 6_ RRAGG 11_ LPDPG 16_ LCGPA 21_ WWAPS 26_ LPRLP 31_ RALPR 36_ LPLLL 41_ LLLLL 46_ QPPAL 51_ SAVFT 56_ VGVLG 61_ PWACD 66_ PIFSR 71_ ARPDL 76_ AARLA 81_ AARLN 86_ RDPGL 91_ AGGPR 96_ FEVAL 101_ LPEPC 106_ RTPGS 111_ LGAVS 116_ SALAR 121_ VSGLV 126_ GPVNP 131_ AACRP 136_ AELLA 141_ EEAGI 146_ ALVPW 151_ GCPWT 156_ QAEGT 161_ TAPAV 166_ TPAAD 171_ ALYAL 176_ LRAFG 181_ WARVA 186_ LVTAP 191_ QDLWV 196_ EAGRS 201_ LSTAL 206_ RARGL 211_ PVASV 216_ TSMEP 221_ LDLSG 226_ AREAL 231_ RKVRD 236_ GPRVT 241_ AVIMV 246_ MHSVL 251_ LGGEE 256_ QRYLL 261_ EAAEE 266_ LGLTD 271_ GSLVF 276_ LPFDT 281_ IHYAL 286_ SPGPE 291_ ALAAL 296_ ANSSQ 301_ LRRAH 306_ DAVLT 311_ LTRHC 316_ PSEGS 321_ VLDSL 326_ RRAQE 331_ RRELP 336_ SDLNL 341_ QQVSP 346_ LFGTI 351_ YDAVF 356_ LLARG 361_ VAEAR 366_ AAAGG 371_ RWVSG 376_ AAVAR 381_ HIRDA 386_ QVPGF 391_ CGDLG 396_ GDEEP 401_ PFVLL 406_ DTDAA 411_ GDRLF 416_ ATYML 421_ DPARG 426_ SFLSA 431_ GTRMH 436_ FPRGG 441_ SAPGP 446_ DPSCW 451_ FDPNN 456_ ICGGG 461_ LEPGL 466_ VFLGF 471_ LLVVG 476_ MGLAG 481_ AFLAH 486_ YVRHR 491_ LLHMQ 496_ MVSGP 501_ NKIIL 506_ TVDDI 511_ TFLHP 516_ HGGTS 521_ RKVAQ 526_ GSRSS 531_ LGARS 536_ MSDIR 541_ SGPSQ 546_ HLDSP 551_ NIGVY 556_ EGDRV 561_ WLKKF 566_ PGDQH 571_ IAIRP 576_ ATKTA 581_ FSKLQ 586_ ELRHE 591_ NVALY 596_ LGLFL 601_ ARGAE 606_ GPAAL 611_ WEGNL 616_ AVVSE 621_ HCTRG 626_ SLQDL 631_ LAQRE 636_ IKLDW 641_ MFKSS 646_ LLLDL 651_ IKGIR 656_ YLHHR 661_ GVAHG 666_ RLKSR 671_ NCIVD 676_ GRFVL 681_ KITDH 686_ GHGRL 691_ LEAQK 696_ VLPEP 701_ PRAED 706_ QLWTA 711_ PELLR 716_ DPALE 721_ RRGTL 726_ AGDVF 731_ SLAII 736_ MQEVV 741_ CRSAP 746_ YAMLE 751_ LTPEE 756_ VVQRV 761_ RSPPP 766_ LCRPL 771_ VSMDQ 776_ APVEC 781_ ILLMK 786_ QCWAE 791_ QPELR 796_ PSMDH 801_ TFDLF 806_ KNINK 811_ GRKTN 816_ IIDSM 821_ LRMLE 826_ QYSSN 831_ LEDLI 836_ RERTE 841_ ELELE 846_ KQKTD 851_ RLLTQ 856_ MLPPS 861_ VAEAL 866_ KTGTP 871_ VEPEY 876_ FEQVT 881_ LYFSD 886_ IVGFT 891_ TISAM 896_ SEPIE 901_ VVDLL 906_ NDLYT 911_ LFDAI 916_ IGSHD 921_ VYKVE 926_ TIGDA 931_ YMVAS 936_ GLPQR 941_ NGQRH 946_ AAEIA 951_ NMSLD 956_ ILSAV 961_ GTFRM 966_ RHMPE 971_ VPVRI 976_ RIGLH 981_ SGPCV 986_ AGVVG 991_ LTMPR 996_ YCLFG 1001_ DTVNT 1006_ ASRME 1011_ STGLP 1016_ YRIHV 1021_ NLSTV 1026_ GILRA 1031_ LDSGY 1036_ QVELR 1041_ GRTEL 1046_ KGKGA 1051_ EDTFW 1056_ LVGRR 1061_ GFNKP 1066_ IPKPP 1071_ DLQPG 1076_ SSNHG 1081_ ISLQE 1086_ IPPER 1091_ RRKLE 1096_KARPG
1: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:15123990, PubMed:21928830, PubMed:26100624, PubMed:30319355, PubMed:9600905). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity)