Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
1_MSVSV 6_ LSPSR 11_ LLGDV 16_ SGILQ 21_ AASLL 26_ ILLLL 31_ LIKAV 36_ QLYLH 41_ RQWLL 46_ KALQQ 51_ FPCPP 56_ SHWLF 61_ GHIQE 66_ LQQDQ 71_ ELQRI 76_ QKWVE 81_ TFPSA 86_ CPHWL 91_ WGGKV 96_ RVQLY 101_ DPDYM 106_ KVILG 111_ RSDPK 116_ SHGSY 121_ RFLAP 126_ WIGYG 131_ LLLLN 136_ GQTWF 141_ QHRRM 146_ LTPAF 151_ HYDIL 156_ KPYVG 161_ LMADS 166_ VRVML 171_ DKWEE 176_ LLGQD 181_ SPLEV 186_ FQHVS 191_ LMTLD 196_ TIMKC 201_ AFSHQ 206_ GSIQV 211_ DRNSQ 216_ SYIQA 221_ ISDLN 226_ NLVFS 231_ RVRNA 236_ FHQND 241_ TIYSL 246_ TSAGR 251_ WTHRA 256_ CQLAH 261_ QHTDQ 266_ VIQLR 271_ KAQLQ 276_ KEGEL 281_ EKIKR 286_ KRHLD 291_ FLDIL 296_ LLAKM 301_ ENGSI 306_ LSDKD 311_ LRAEV 316_ DTFMF 321_ EGHDT 326_ TASGI 331_ SWILY 336_ ALATH 341_ PKHQE 346_ RCREE 351_ IHSLL 356_ GDGAS 361_ ITWNH 366_ LDQMP 371_ YTTMC 376_ IKEAL 381_ RLYPP 386_ VPGIG 391_ RELST 396_ PVTFP 401_ DGRSL 406_ PKGIM 411_ VLLSI 416_ YGLHH 421_ NPKVW 426_ PNPEV 431_ FDPFR 436_ FAPGS 441_ AQHSH 446_ AFLPF 451_ SGGSR 456_ NCIGK 461_ QFAMN 466_ ELKVA 471_ TALTL 476_ LRFEL 481_ LPDPT 486_ RIPIP 491_ IARLV 496_ LKSKN 501_ GIHLR 506_ LRRLP 511_NPCED
1: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927)