Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)
1_MAATA 6_ SAGAG 11_ GIDGK 16_ PRTSP 21_ KSVKF 26_ LFGGL 31_ AGMGA 36_ TVFVQ 41_ PLDLV 46_ KNRMQ 51_ LSGEG 56_ AKTRE 61_ YKTSF 66_ HALTS 71_ ILKAE 76_ GLRGI 81_ YTGLS 86_ AGLLR 91_ QATYT 96_ TTRLG 101_ IYTVL 106_ FERLT 111_ GADGT 116_ PPGFL 121_ LKAVI 126_ GMTAG 131_ ATGAF 136_ VGTPA 141_ EVALI 146_ RMTAD 151_ GRLPA 156_ DQRRG 161_ YKNVF 166_ NALIR 171_ ITREE 176_ GVLTL 181_ WRGCI 186_ PTMAR 191_ AVVVN 196_ AAQLA 201_ SYSQS 206_ KQFLL 211_ DSGYF 216_ SDNIL 221_ CHFCA 226_ SMISG 231_ LVTTA 236_ ASMPV 241_ DIAKT 246_ RIQNM 251_ RMIDG 256_ KPEYK 261_ NGLDV 266_ LFKVV 271_ RYEGF 276_ FSLWK 281_ GFTPY 286_ YARLG 291_ PHTVL 296_ TFIFL 301_ EQMNK 306_AYKRL
1: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity)