Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)
1_MSMTL 6_ GYWDI 11_ RGLAH 16_ AIRLL 21_ LEYTD 26_ SSYEE 31_ KKYTM 36_ GDAPD 41_ YDRSQ 46_ WLNEK 51_ FKLGL 56_ DFPNL 61_ PYLID 66_ GAHKI 71_ TQSNA 76_ ILCYI 81_ ARKHN 86_ LCGET 91_ EEEKI 96_ RVDIL 101_ ENQAM 106_ DVSNQ 111_ LARVC 116_ YSPDF 121_ EKLKP 126_ EYLEE 131_ LPTMM 136_ QHFSQ 141_ FLGKR 146_ PWFVG 151_ DKITF 156_ VDFLA 161_ YDVLD 166_ LHRIF 171_ EPNCL 176_ DAFPN 181_ LKDFI 186_ SRFEG 191_ LEKIS 196_ AYMKS 201_ SRFLP 206_ KPLYT 211_RVAVW
1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009)