Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH)
1_MQYPH 6_ PGPAA 11_ GAVGV 16_ PLYAP 21_ TPLLQ 26_ PAHPT 31_ PFYIE 36_ DILGR 41_ GPAAP 46_ TPAPT 51_ LPSPN 56_ SSFTS 61_ LVSPY 66_ RTPVY 71_ EPTPI 76_ HPAFS 81_ HHSAA 86_ ALAAA 91_ YGPGG 96_ FGGPL 101_ YPFPR 106_ TVNDY 111_ THALL 116_ RHDPL 121_ GKPLL 126_ WSPFL 131_ QRPLH 136_ KRKGG 141_ QVRFS 146_ NDQTI 151_ ELEKK 156_ FETQK 161_ YLSPP 166_ ERKRL 171_ AKMLQ 176_ LSERQ 181_ VKTWF 186_ QNRRA 191_ KWRRL 196_ KQENP 201_ QSNKK 206_ EELES 211_ LDSSC 216_ DQRQD 221_ LPSEQ 226_ NKGAS 231_ LDSSQ 236_ CSPSP 241_ ASQED 246_ LESEI 251_ SEDSD 256_ QEVDI 261_EGDKS
1: Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636)