cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)
1_MTMET 6_ VESQH 11_ DGSIT 16_ ASLTE 21_ SKSAH 26_ VQTQT 31_ GQNSI 36_ PALAQ 41_ VSVAG 46_ SGTRR 51_ GSPAV 56_ TLVQL 61_ PSGQT 66_ IHVQG 71_ VIQTP 76_ QPWVI 81_ QSSEI 86_ HTVQV 91_ AAIAE 96_ TDESA 101_ ESEGV 106_ IDSHK 111_ RREIL 116_ SRRPS 121_ YRKIL 126_ NELSS 131_ DVPGV 136_ PKIEE 141_ ERSEE 146_ EGTPP 151_ SIATM 156_ AVPTS 161_ IYQTS 166_ TGQYI 171_ AIAQG 176_ GTIQI 181_ SNPGS 186_ DGVQG 191_ LQALT 196_ MTNSG 201_ APPPG 206_ ATIVQ 211_ YAAQS 216_ ADGTQ 221_ QFFVP 226_ GSQVV 231_ VQDEE 236_ TELAP 241_ SHMAA 246_ ATGDM 251_ PTYQI 256_ RAPTA 261_ ALPQG 266_ VVMAA 271_ SPGSL 276_ HSPQQ 281_ LAEEA 286_ TRKRE 291_ LRLMK 296_ NREAA 301_ KECRR 306_ RKKEY 311_ VKCLE 316_ SRVAV 321_ LEVQN 326_ KKLIE 331_ ELETL 336_KDICS
1: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550)
2: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter